116 Result(s)
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Article
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
The longitudinal growth of the skeleton arises from the continuous process of endochondral ossification occurring at the ends of growing long bones. Dwarfism results when this process is disrupted, as in the a...
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Article
An Improved Optimization Strategy and Its Application to Clustering Analysis
In this paper, a new optimization strategy is put forward which locates as many potential unimodal regions as possible in the search space. The potential optima can be further explored by a global optimization...
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Chapter and Conference Paper
Value of Information Analysis in Dynamic Influence Diagrams
Value of information calculation is an important tool for sensitive analysis in intelligent normative decision systems. In this paper, we study the time invariant features in models represented as dynamic infl...
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Chapter
Extracellular Matrix in the Regulation of Angiogenesis
The cardiovascular system plays critical roles in vertebrate development and homeostasis. A crucial process within this system involves the establishment of functional blood vessels. Over the last decade vascu...
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Article
A New Approach to the Architecture Optimization of a General 3-PUU Translational Parallel Manipulator
This paper presents a new approach to the architecture optimization of a general 3-PUU translational parallel manipulator (TPM) based on the performance of a weighted sum of global dexterity index and a new pe...
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Chapter and Conference Paper
A 3-PRS Parallel Manipulator Control Based on Neural Network
Due to the time-consuming calculation for the forward kinematics of a 3-PRS (prismatic-revolute-spherical) parallel manipulator, neither the kinematic nor dynamic control algorithm can be implemented on real t...
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Article
Chemometrics and modernization of traditional Chinese medicine
Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines (TCMs) are discussed. The quality control methods for guara...
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Article
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins
To kill pathogens, neutrophils must be able to transmigrate into tissues. Xu and colleagues show that the kinase MYLK, by phosphorylating Pyk2, is required for neutrophils to reach sites of infection.
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Chapter and Conference Paper
CMAC-Based PID Control of an XY Parallel Micropositioning Stage
This paper presents the controller design of an XY parallel micropositioning stage aiming at a sub-micron accuracy for micro scale manipulation. Owning to the decoupled design of the mechanism, a simple single...
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Article
Design and Optimization of an XYZ Parallel Micromanipulator with Flexure Hinges
In this paper, a nearly decoupled XYZ translational compliant parallel micromanipulator (CPM) is designed for micro/nano scale manipulation with features of piezo-driven actuators and flexure hinges. The CPM s...
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Chapter
Fuzzy Sliding Mode Control with Perturbation Estimation for a Piezoactuated Micromanipulator
This paper is concentrated on control system design for an XY parallel micromanipulator with piezoelectric actuation. The decoupled property of the manipulator enables the employment of single-input-single-out...
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Article
Chitooligosaccharides Protect Human Embryonic Hepatocytes Against Oxidative Stress Induced by Hydrogen Peroxide
Chitooligosaccharides (COS) has many biological activities, such as antitumor activity and hepatoprotective effect. Herein, we investigated the protective effect of COS against hydrogen peroxide (H2O2)-induced ox...
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Chapter and Conference Paper
Fault Diagnosis of Automotive Engines Using Fuzzy Relevance Vector Machine
For any faults of automotive engines, the diagnosis can be performed based on variety of symptoms. Traditionally, the description of the faulty symptom is just existence or not. However, this description canno...
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Chapter and Conference Paper
Rate-Dependent Hysteresis Modeling and Compensation Using Least Squares Support Vector Machines
This paper is concentrated on the rate-dependent hysteresis modeling and compensation for a piezoelectric actuator. A least squares support vector machines (LS-SVM) model is proposed and trained by introducing...
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Article
Toward better QSAR/QSPR modeling: simultaneous outlier detection and variable selection using distribution of model features
Building a robust and reliable QSAR/QSPR model should greatly consider two aspects: selecting the optimal variable subset from a large pool of molecular descriptors and detecting outliers from a pool of sample...
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Article
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases
Neutrophils are early responders and must navigate using spatial cues to arrive at infection sites. Xu and colleagues show that the opposing activities of MAP kinases Erk and p38 govern neutrophil migration.
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Article
Potential roles of N-glycosylation in cell adhesion
The functional units of cell adhesion are typically multiprotein complexes made up of three general classes of proteins; the adhesion receptors, the cell-extracellular matrix (ECM) proteins, and the cytoplasmi...
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Chapter
Introduction: Smart Materials as Essential Base for Actuators in Micro/Nanopositioning
The main motivations of using smart materials as fundamental in micro/ nanopositioning systems are presented in this chapter. It is shown that the design of classical (or macro) actuated systems cannot directl...
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Chapter
Intelligent Hysteresis Modeling and Control of Piezoelectric Actuators
This chapter presents a new approach to hysteresis modeling and compensation of piezoelectric actuators by resorting to an intelligent model. A least squares support vector machine (LSSVM)-based hysteresis mod...
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Article
Effect of annealing temperature on the energy transfer in Eu-doped ZnO nanoparticles by chemical precipitation method
Eu-doped ZnO nanoparticles were synthesized by the chemical precipitation method and the annealing temperature effect on the structures and photoluminescence (PL) properties of the nanoparticles were briefly i...
