-
Article
Investigation of mountainous laser texturing for improving the adhesion and tribological properties of AlCrN coatings
The effect of mountainous laser texturing on improving the interfacial adhesion and tribological properties of WC-TiC-Co-based AlCrN coatings was studied, which is crucial for the durability of AlCrN coatings....
-
Article
Machinability Investigation and Sustainability Assessment of Dry Cutting AISI1045 Steel Using Tools Configured with Shark-Skin-Inspired Structures and WS2/C Coatings
This paper primarily determined the suitable technique for the preparation of WS2/C coating by the analytical hierarchy process (AHP) with a keen focus on the criteria of coating property, deposition process, res...
-
Article
Effect of micro textures on the cutting performance of circular saw blade
In this paper, linear micro textures that parallel to the sawtooth edge were fabricated on the surface of the high-speed steel W6Mo5Cr4V2 circular saw blade by laser engraving. Furthermore, cutting performance...
-
Article
Effect of micro-textures on cutting fluid lubrication of cemented carbide tools
Severe friction at the cutter-chip interface increases tool surface wear and reduces tool life. The friction could be reduced by introducing cutting fluids between cutter and chip. The lubrication of cutting f...
-
Article
A thermo-mechanical coupled model of derivative cutting of microtextured tools
In our previous works, the revelation of the significance of derivative cutting in the cutting process with microtextured tools, which occurs because of the finite sharpness of the texture edge at the tool-chi...
-
Article
An approach to predict derivative-chip formation in derivative cutting of micro-textured tools
Derivative cutting of micro-textured tool refers to the additional cutting to the bottom side of the chip with the micro-surface textures on the tool surface. In our previous research, it has been proved that ...
-
Article
Open AccessDifferential Serum Cytokine Profiles in Patients with Chronic Hepatitis B, C, and Hepatocellular Carcinoma
Cytokines play an important role in the pathogenesis of cirrhosis and hepatocellular carcinoma (HCC), most cases of which are related to either hepatitis B virus (HBV) or hepatitis C virus (HCV). Prior studies...
-
Article
Open AccessSoluble intercellular adhesion molecule-1 is associated with hepatocellular carcinoma risk: multiplex analysis of serum markers
Individualized assessment of hepatocellular carcinoma (HCC) risk in chronic liver disease remains challenging. Serum biomarkers including cytokines may offer helpful adjuncts to standard parameters for risk pr...
-
Article
Urinary norepinephrine and epinephrine excretion rates are heritable, but not associated with office and ambulatory blood pressure
Genetic and environmental contributions to urinary excretion rates of norepinephrine (UNEV) and epinephrine (UEV) and their association with blood pressure (BP) were investigated in 91 African American (mean age,...
-
Article
Erratum to: The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection
-
Article
Open AccessPersonal receptor repertoires: olfaction as a model
Information on nucleotide diversity along completely sequenced human genomes has increased tremendously over the last few years. This makes it possible to reassess the diversity status of distinct receptor pro...
-
Article
The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection
Single-nucleotide polymorphisms (SNPs) in the IL28B and PNPLA3 gene regions have been associated with hepatic steatosis in genotype 1 (G1) chronic HCV infection but their clinical impacts remain to be determined...
-
Article
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease.
-
Article
Open AccessScreening the human exome: a comparison of whole genome and whole transcriptome sequencing
There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, wh...
-
Article
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
The standard treatment for chronic hepatitis C infection, pegylated interferon (pegIFN) and ribavirin (RBV), carries a range of unpleasant side effects including haemolytic anaemia. Now a genome-wide associati...
-
Article
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
Mary Carrington and colleagues follow up on an earlier association of a variant upstream of HLA-C to HIV viral load setpoint, showing that this variant is associated with high HLA-C cell surface expression and de...
-
Article
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, leading in many cases to chronic liver disease. Here the authors show that an SNP recently identified to associa...
-
Article
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Hepatitis C is one of the most common infections in the world. Many of its estimated 170 million sufferers live with the disease for years with no serious symptoms, but in about one in four patients it leads t...
-
Article
Common variants conferring risk of schizophrenia
Based on its symptoms, schizophrenia has been considered a discrete disease, and yet genome-wide association studies for copy number variations (CNVs) associated with the disease have revealed that some CNVs c...
-
Article
Large recurrent microdeletions associated with schizophrenia
The genetics of schizophrenia and other mental disorders are complex and poorly understood, and made even harder to study because reduced reproduction rates result in negative selection pressure on risk allele...
