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  1. Article

    Open Access

    The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

    Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemi...

    Kevin W. O’Connor, Kensei Kishimoto, Irena O. Kuzma, Kelsey P. Wagner… in Leukemia (2024)

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    Article

    Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

    In studies in mammalian cells, polymerase theta (Polθ, also known as POLQ) is identified as the polymerase responsible for non-homologous end joining DNA repair; this DNA repair pathway acts in many tumours wh...

    Raphael Ceccaldi, Jessica C. Liu, Ravindra Amunugama, Ildiko Hajdu… in Nature (2015)

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    Chapter

    Congressional Perspectives

    Legal, economic, ethical, and social issues relating to animal patents were the subject of hearings and legislation during the 100th US Congress. The purpose of this paper is to explain why Congress is interes...

    Kevin W. O’Connor in Animal Patents (1989)