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Article
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis
Whether epigenetic modifications participate in the cell apoptosis after ischemic stroke remains unclear. Histone 3 tri-methylation at lysine 27 (H3K27me3) is a histone modification that leads to gene silencin...
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Article
Fabrication of lightweight, tough polypropylene composite foams: effects of nucleating agent structure on the foaming behavior and tensile property of polypropylene foams
The type and structure of nucleating agents have an important influence on the properties of the final foam as well as on the nucleation of the bubbles during injection foaming. In this study, a simple melt bl...
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Article
Climate change induced Melamchi extreme flood and environment implication in central Himalaya of Nepal
Flood occurred in the Melamchi River on June 15 and recurred on July 31, 2021 have led notorious impacts in Nepal. This study has investigated these extreme flood events and their nexus with climate i.e. preci...
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Article
Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate
Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP), are known to cause male reproductive damage. Lactiplantibacillus plantarum RS20D has demons...
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Article
Experimental Investigation of the Effect of Core Structures on Low-Velocity Impact Response of PEEK Sandwich Panels Manufactured by FDM
To improve the dynamic performance of sandwich panels, a bamboo bio-inspired core structural sandwich panel was designed, and two other general structures of sandwich panels, namely, cubic and honeycomb, were ...
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Article
A low noise and wide dynamic range preamplifier for HPGe detectors
HPGe detectors can be used for both dark matter search and neutrinoless double beta decay experiments. However, signal amplitudes of these two experiments are quite different. This paper presents the developme...
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Article
Direct observation of Landau levels in silicon photonic crystals
When electrons are confined to a two-dimensional plane and are subjected to an out-of-plane magnetic field, they move in circular cyclotron orbits as a result of the Lorentz force. In the quantum domain, this ...
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Article
Open AccessDietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue
The high-protein diet (HPD) has emerged as a potent dietary approach to curb obesity. Peroxisome, a highly malleable organelle, adapts to nutritional changes to maintain homeostasis by remodeling its structure...
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Article
Open AccessThe influence of an urban hukou and its acquisition methods on older adults’ happiness: an analysis based on the Chinese General Social Survey
The hukou system is a population management policy in China. However, existing research has paid little attention to the relationships between Chinese urban hukou, its acquisition methods, and older adults’ ha...
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Article
Effects of aqueous nanoparticle suspension injection on a shale’s mechanical properties
This paper presents the first effort to unravel and quantify the strengthening of a shale induced by nanoparticle injection from the perspectives of cross-scale and multi-constituent mechanical properties. Aft...
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Article
Open AccessThe casual relationship between autoimmune diseases and multiple myeloma: a Mendelian randomization study
Observational studies showed possible associations between systemic lupus erythematosus and multiple myeloma. However, whether there is a casual relationship between different types of autoimmune diseases (typ...
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Article
Fabricating Composite Cell Sheets for Wound Healing: Cell Sheets Based on the Communication Between BMSCs and HFSCs Facilitate Full-Thickness Cutaneous Wound Healing
Insufficient angiogenesis and the lack of skin appendages are critical challenges in cutaneous wound healing. Stem cell-fabricated cell sheets have become a promising strategy, but cell sheets constructed by a...
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Article
Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study
Both metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent in major depressive disorder (MDD) patients. However, their relationship in this population remains unknown. The study assessed...
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Article
Composition operators with closed range on the Dirichlet space
It is well known that the composition operator on Hardy or Bergman space has a closed range if and only if its Nevanlinna counting function induces a reverse Carleson measure. Similar conclusion is not availab...
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Article
Open AccessLifestyle factors and subacromial im**ement syndrome of the shoulder: potential associations in finnish participants
Emerging evidence has indicated the associations between subacromial im**ement syndrome (SIS) of shoulder and lifestyle factors. However, whether unhealthy lifestyle factors causally increase SIS risk is not...
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Article
Open AccessDe novo-designed transmembrane proteins bind and regulate a cytokine receptor
Transmembrane (TM) domains as simple as a single span can perform complex biological functions using entirely lipid-embedded chemical features. Computational design has the potential to generate custom tool mo...
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Article
A rare stroke mimic: neuronal intranuclear inclusion disease
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Article
Open AccessGasless transvaginal natural orifice transluminal endoscopic surgery for hysterectomy and sal**ectomy on a robot platform with flexible devices in a porcine model
In this report, we described a new technique of gasless V-NOTES for hysterectomy and sal**ectomy on a robotic platform with flexible devices in a porcine model. As a result, the gynecological procedures were...
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Article
Validity of evoked potential as biomarker for predicting early neural function changes after thoracic spinal decompression surgery in patients with neurological deficits
To evaluate the validity of intraoperative evoked potential (EP) including motor evoked potential (MEP) and somatosensory evoked potentials (SEP) as a biomarker for predicting neural function changes after tho...
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Article
Open AccessFor freedom or income? Depression among independent self-employed individuals and the mediating mechanisms: empirical evidence from China
Independent self-employment (ISE) has a crucial impact on new job creation as well as sustainable and inclusive growth. However, the findings on depression status among self-employed individuals are mixed owin...
