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Article
Open AccessTreatment with β-Adrenoceptor Agonist Isoproterenol Reduces Non-parenchymal Cell Responses in LPS/D-GalN-Induced Liver Injury
There is an increasing evidence indicating the involvement of the sympathetic nervous system (SNS) in liver disease development. To achieve an extensive comprehension of the obscure process by which the SNS al...
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Article
Open AccessC/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription
Acute myeloid leukemia (AML) with biallelic (CEBPAbi) as well as single mutations located in the bZIP region is associated with a favorable prognosis, but the underlying mechanisms are still unclear. Here, we pro...
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Article
Open AccessCytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies
Although the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical application is hampered by the complexity and fatality of its side effe...
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Article
Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response
Surface micro-area potential difference (MAPD) can achieve bacteriostatic performance independent of metal ion dissolution. To study the influence of MAPD on antibacterial properties and the cellular response,...
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Article
HBV reactivation in patients with chronic or resolved HBV infection following BCMA-targeted CAR-T cell therapy
B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor-T cell (CAR-T) therapy is used for refractory or relapsed multiple myeloma (r/r MM). Concern of the safety and efficacy of CAR-T cell therapy...
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Chapter and Conference Paper
Research on RGB-d-Based Pilot Hand Detection in Complex Cockpit Environment
With the rapid development of the aviation industry, human error has replaced mechanical failure as the main cause of aviation accidents, which makes “human factors” increasingly popular. In human factors rese...
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Chapter and Conference Paper
The Effects of Expertise on Airline PILOT’S Eye Activities in Flight Tasks with Different Complexity
Information processing remains one of the key elements of aviation safety, and eye is the most essential sensory organ as it almost processed 80% of flight information. In order to improve the operating effici...
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Chapter and Conference Paper
The Similarity Recognition of Pilots’ Operational Action Sequence Based on Blocked Dynamic Time War** during a Flight Mission
Human errors are the primary cause of aviation safety accidents. It is necessary to identify the potential operation errors of a crew during a flight task. In this work, we propose a flight mission recognition...
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Chapter and Conference Paper
Modelling Causal Relationship Among Performance Sha** Factors Through Bayesian Network on Aviation Safety
Aviation safety is greatly influenced by pilot performance reliability. To assess the reliability, many human reliability analysis (HRA) methods are developed. Currently, in most HRA methods performance shapin...
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Chapter and Conference Paper
Simulation Study on Civil Aviation Human Reliability Learning from Incidents Using System Dynamics
Flight safety is the foundation and guarantee of the sustainable development of the civil aviation industry. With the continuous development of the aircraft industry, fewer and fewer accidents are caused solel...
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Article
Studies on the Catalytic Activities of Cp2ZrCl2 in Olefin Polymerizations that was In-Situ Synthesized or Adsorbed on Organosilaneized Surface of Spherical Silica Gel
Cp2ZrCl2, a kind of catalyst for olefin polymerization, was in-situ synthesized on the chain of N1,N2-bis(2-(triethoxysilyl)ethyl)oxalamide connected on the surface of spherical silica gel, and the composite cata...
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Article
Open AccessPreparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and humoral immunity. This study prepared an adenoviral vector-sp...
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Chapter and Conference Paper
Ergonomic Evaluation of the Touch Screen in the Cockpit Under Stationary and Vibration Conditions
Compared with the traditional input mode, the touch screen has the advantages of convenient operation and saving cockpit space. As the touch screen began to appear in the aircraft cockpit, the impact of turbul...
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Chapter and Conference Paper
Compensation Method of Flight Simulator Visual System
The Stewart 6DOF motion platform is widely used in flight simulators. However, due to performance and parameter limitations, many Stewart motion platforms cannot meet the acceleration and motion range requirem...
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Chapter and Conference Paper
The Effect of Pilots’ Expertise on Eye Movement and Scan Patterns During Simulated Flight Tasks
In aviation safety nowadays, pilot errors are responsible for most accidents, instead of the failure of aircrafts. Human factors aims at reducing pilot-related errors and improving safety. Eye movement has bee...
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Chapter and Conference Paper
Corpus Construction for Aviation Speech Recognition
In the aviation field, safety is always the top priority. Human error is one of the important factors affecting flight safety, which may cause serious consequences. Since voice conversation is the primary way ...
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Chapter and Conference Paper
The Assessment of Aviation Situation Awareness Based on Objective Behavior Methods
Situation awareness assessment is one of the current focuses of aviation human factors research. In response to the current demand for real-time and interpretable situation awareness measurement, this study ad...
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Chapter and Conference Paper
A Cargo Throughput Capacity Quantization Estimation Using Semi-Markov Jump System Filter Within Partial State Delay
Cargo throughput capacity is a very important and basic indicator for port expansion and operation and maintenance. As a non-linear dynamic indicator affected by multiple variables, timely estimation of cargo ...
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Article
Open AccessEnhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells
Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor ...
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Article
Open AccessShort-term and long-term safety and efficacy of tenofovir alafenamide, tenofovir disoproxil fumarate and entecavir treatment of acute-on-chronic liver failure associated with hepatitis B
There is limited evidence on the efficacy and safety of nucleos(t) ide analogues (NAs) in the treatment of HBV-ACLF. Our objective was to evaluate the outcomes among TAF, TDF and ETV, three first-line antivira...
