2,253 Result(s)
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Article
Enhanced population of excited single state strategy: irradiation and ultrasound dual-response and host tumor-driven nano-sensitizers construction in triple synergistic therapy
Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species (ROS), bio-images, and high temperatures. All of the...
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Efficient electrocatalytic reduction of nitrate to ammonia at low concentration by copper-cobalt oxide nanowires with shell–core structure
Electrocatalytic nitrate reduction to ammonia (NO3−RR) for removing nitrate from wastewater is a promising but challengeable technology that is increasingly studied. Herein, we developed an efficient CuOx and CoC...
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Open AccessDynamic feedback algorithm based on spatial corner fitness for solving the three-dimensional multiple bin-size bin packing problem
To improve cargo loading efficiency and achieve diverse needs of companies for the loading process, this paper innovatively establishes a multiple objective mixed integer programming model for the three-dimens...
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Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission
Hepatocellular carcinoma (HCC) is highly metastatic and invasive. CircRNA participates in gene regulation of multiple tumor metastases, but little is known whether it is a bystander or an actual player in HCC ...
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GLI1 polymorphisms influence remission rate and prognosis of young de novo acute myeloid leukemia patients treated with cytarabine-based chemotherapy
Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy. Cytarabine (Ara-C)-based chemotherapy is the primary treatment for AML, but currently known prognostic risk stratification facto...
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Open AccessThree-dimensional DNA nanomachine biosensor coupled with CRISPR Cas12a cascade amplification for ultrasensitive detection of carcinoembryonic antigen
The detection of carcinoembryonic antigen (CEA) holds significant importance in the early diagnosis of cancer. However, current methods are hindered by limited accessibility and specificity. This study propose...
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Open AccessDiagnostic performance of regional systematic biopsy for prostate cancer stratified by PI-RADS and histologic zones
To explore the diagnostic performance of targeted biopsy (TB) combined with regional systematic biopsy (RSB) in patients with different Prostate Imaging Reporting and Data System (PI-RADS) and histologic zones...
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Unravelling the Tip Effect of Oxygen Catalysis in Integrated Cathode for High-Performance Flexible/Wearable Zn–Air Batteries
The exploration of high-efficiency transition metal–nitrogen–carbon (M–N–C) catalysts is crucial for accelerating the kinetics of oxygen reduction/oxygen evolution reactions (ORR/OER). Fine-tuning the distribu...
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Article
Multiple attribute group decision-making based on the ExpTODIM method and linguistic Pythagorean operators
The linguistic Pythagorean fuzzy sets (LPFSs) are productive and advantageous when decision makers (DMs) express evaluation information in decision making problems (DMPs). Due to the variability of parameters,...
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EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer
This study examines the prognostic role and immunological relevance of EMP1 (epithelial membrane protein-1) in a pan-cancer analysis, with a focus on ovarian cancer. Utilizing data from TCGA, CCLE, and GTEx da...
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Article
A High-Order Shifted Boundary Virtual Element Method for Poisson Equations on 2D Curved Domains
We consider a high-order virtual element method for Poisson problems with non-homogeneous Dirichlet boundary condition on 2D domains with curved boundary. The scheme is designed on unfitted polygonal meshes. I...
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Dynamic Mechanical Response and Fracture Characteristics of Multi-flawed Rocks Exposed to Hydrostatic Confinements
Flawed rocks subjected to hydrostatic confinements in deep underground engineering are vulnerable to dynamic disturbances. Understanding the dynamic mechanical responses and fracture characteristics of flawed ...
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Open AccessMyeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization
Inflammatory bowel disease (IBD) is characterized by inflammatory conditions in the gastrointestinal tract. According to reports, IBD prevalence is increasing globally, with heavy economic and physical burdens...
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Safety, pharmacokinetics, and food-effect of pivmecillinam after single- and multiple-dose in healthy Chinese subjects: a phase I study
Urinary tract infection (UTI) is one of the most prevalent bacterial infectious diseases worldwide. However, the resistance of urinary pathogens to other UTI antibiotics such as trimethoprim and trimethoprim/s...
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Open AccessTM7SF2-induced lipid reprogramming promotes cell proliferation and migration via CPT1A/Wnt/β-Catenin axis in cervical cancer cells
Cervical cancer poses a serious threat to women’s health globally. Our previous studies found that upregulation of TM7SF2, which works as an enzyme involved in the process of cholesterol biosynthesis expressio...
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Article
Low-Dose CT Denoising Algorithm Based on Image Cartoon Texture Decomposition
Low-dose computed tomography (LDCT) technology has attracted more and more attention in the field of medical imaging because of the reduction of radiation damage to the human body. However, the large amount of...
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Open AccessPan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
Interleukin-4 inducible gene 1 (IL4I1) regulates tumor progression in numerous tumor types. However, its correlation with immune infiltration and prognosis of patients in a pan-cancer setting remains unclear.
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Enhancing heart failure diagnosis through multi-modal data integration and deep learning
In the realm of medical data processing, the surge in electronic health records has opened avenues for addressing clinical challenges. Although machine and deep learning methods have gained traction, they ofte...
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Accelerating similarity-based model matching using dual hashing
Similarity-based model matching is the cornerstone of model versioning. It pairs model elements based on a distance metric (e.g., edit distance). However, calculating the distances between elements is computat...
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Tissue-like P systems with polarizations