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Article
In Situ Assembly of Melittin-PHA Microspheres for Enhancing Therapeutic Efficacy in Cancer Treatment
Amphiphilic cationic peptide (ACP) is a widely studied biofilm-active peptide that has great potential in cancer treatment. However, poor stability, a short half-life, and complex preparation pose significant ...
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Article
Cytogenetic analysis reveals a mechanism of compatibility in distant hybridization between tree peony and herbaceous peony
Cross-incompatibility is the major challenge in inter-sectional distant hybridization between tree peonies (Paeonia sect. Moutan) and herbaceous peonies (Paeonia sect. Paeonia). Most of the intersectional cross c...
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Article
Open AccessATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia–reperfusion injury
Cardiac resident MerTK+ macrophages exert multiple protective roles after ischemic injury; however, the mechanisms regulating their fate are not fully understood. In the present study, we show that the GAS6-induc...
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Article
Claudin-5 overexpression correlates with proliferation and migration in gastric cancer
Gastric cancer (GC) is a common malignant tumor of the digestive tract. Claudin-5 is upregulated in GC tumor tissues, but its effect on GC is imprecise. In this study, we analyzed the influence of claudin-5 on...
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Article
Isolation and characterization of tumorigenic bacteria associated with crown gall disease of Prunus humilis Bunge in China
Prunus humilis Bunge (Cerasus humilis (Bunge) S. ya. Sokolov) (Rosaceae) is a small shrub native to China, highly valued for environmental protection and as a functional food. However, with the increasing scale o...
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Article
Open AccessWnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC d...
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Article
Fine map** of powdery mildew and stripe rust resistance genes Pm5V/Yr5V transferred from Dasypyrum villosum into wheat without yield penalty
The novel wheat powdery mildew and stripe rust resistance genes Pm5V/Yr5V are introgressed from Dasypyrum villosum and fine mapped to a narrowed region in 5VS, and their effects on yield-related traits were chara...
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Article
Machine learning-based estimates of aboveground biomass of subalpine forests using Landsat 8 OLI and Sentinel-2B images in the Jiuzhaigou National Nature Reserve, Eastern Tibet Plateau
Accurate estimates of forest aboveground biomass (AGB) are critical for supporting strategies of ecosystem conservation and climate change mitigation. The Jiuzhaigou National Nature Reserve, located in Eastern...
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Article
Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction
Serum aldosterone is associated with cardiac remodeling, which contributes to morbidity and mortality in heart failure (HF); however, the prognostic value of aldosterone in HF with a preserved ejection fractio...
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Article
β-Aminoisobutyric acid supplementation attenuated salt-sensitive hypertension in Dahl salt-sensitive rats through prevention of insufficient fumarase
The human Dietary Approaches to Stop Hypertension-Sodium Trial has shown that β-aminoisobutyric acid (BAIBA) may prevent the development of salt-sensitive hypertension (SSHT). However, the specific antihyperte...
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Article
Enhanced Production of Iturin A-2 Generated from Bacillus velezensis T701 and the Antitumor Activity of Iturin A-2 against Human Gastric Carcinoma Cells
Bacillus velezensis T701 was used to produce lipopeptide. Among the lipopeptide, iturin A-2 was of the highest antitumor activity. In order to get higher yield of iturin A-2, the fermentation conditions of strain...
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Article
Production, Purification and Characterization of ‘Iturin A-2’ a Lipopeptide with Antitumor Activity from Chinese Sauerkraut Bacterium Bacillus velezensis T701
This study was done to purify and characterize antitumor lipopeptide from Bacillus strains. Bacillus velezensis strain T701, which was isolated from Chinese sauerkraut, was screened out for its antitumor activity...
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Article
Open AccessZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells
Vitamin D receptor (VDR) plays a vital protective role in oral and colonic epithelial cells. Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism...
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Article
The optimal number of embryo cells for effective pregnancy and decrease of multiple pregnancy rate in frozen-thawed embryo transfer
To investigate the effect of the number of embryo cells on the clinical outcome of frozen-thawed embryo transfer and explore the optimal policy for decreases of multiple pregnancy rate, patients who experience...
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Article
Open AccessTranscriptomic, proteomic, and physiological comparative analyses of flooding mitigation of the damage induced by low-temperature stress in direct seeded early indica rice at the seedling stage
Low temperature (LT) often occurs at the seedling stage in the early rice-growing season, especially for direct seeded early-season indica rice, and using flooding irrigation can mitigate LT damage in rice seedli...
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Article
Open AccessCombined proteomics, metabolomics and physiological analyses of rice growth and grain yield with heavy nitrogen application before and after drought
Nitrogen application can effectively mitigate the damage to crop growth and yield caused by drought. However, the efficiency of heavy nitrogen application before drought (NBD) and heavy nitrogen application af...
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Article
Open AccessHigh-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated the mechanism whereby long-term high-fat diet (HFD) feeding in...
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Article
Oral Administration of Strontium Gluconate Effectively Reduces Articular Cartilage Degeneration Through Enhanced Anabolic Activity of Chondrocytes and Chondrogenetic Differentiation of Mesenchymal Stromal Cells
Osteoarthritis (OA), a common degenerative disease affecting articular cartilage, is caused by multiple factors, and currently, there are few approaches to effectively delay its progression. This study aimed t...
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Article
Open AccessMicroRNA-26a/b have protective roles in oral lichen planus
Oral lichen planus (OLP) is a kind of oral epithelial disorder featured with keratinocyte apoptosis and inflammatory reaction. The pathogenesis of OLP remains an enigma. Herein, we showed that the levels of mi...
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Article
Open AccessHypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment
The process of vascular remodeling is associated with increased hypoxia. However, the contribution of hypoxia-inducible factor 1α (HIF1α), the key transcription factor mediating cellular hypoxic responses, to ...
