27 Result(s)
within
Pharmacology/Toxicology
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Article
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
Calcific aortic valve stenosis (CAVS) is characterized by increasing inflammation and progressive calcification in the aortic valve leaflets and is a major cause of death in the aging population. This study ai...
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Article
In Situ Assembly of Melittin-PHA Microspheres for Enhancing Therapeutic Efficacy in Cancer Treatment
Amphiphilic cationic peptide (ACP) is a widely studied biofilm-active peptide that has great potential in cancer treatment. However, poor stability, a short half-life, and complex preparation pose significant ...
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Article
Open AccessThe Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury
Oxidative stress is a frequently occurring pathophysiological feature of spinal cord injury (SCI) and can result in secondary injury to the spinal cord and skeletal muscle atrophy. Studies have reported that g...
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Article
Claudin-5 overexpression correlates with proliferation and migration in gastric cancer
Gastric cancer (GC) is a common malignant tumor of the digestive tract. Claudin-5 is upregulated in GC tumor tissues, but its effect on GC is imprecise. In this study, we analyzed the influence of claudin-5 on...
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Article
Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function
Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial dynamics enhances mitophagy an...
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Article
Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling
Peroxisome proliferator-activated receptor α (PPARα), a ligand-activated nuclear receptor critical for systemic lipid homeostasis, has been shown closely related to cardiac remodeling. However, the roles of ca...
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Article
Enhanced Production of Iturin A-2 Generated from Bacillus velezensis T701 and the Antitumor Activity of Iturin A-2 against Human Gastric Carcinoma Cells
Bacillus velezensis T701 was used to produce lipopeptide. Among the lipopeptide, iturin A-2 was of the highest antitumor activity. In order to get higher yield of iturin A-2, the fermentation conditions of strain...
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Article
Production, Purification and Characterization of ‘Iturin A-2’ a Lipopeptide with Antitumor Activity from Chinese Sauerkraut Bacterium Bacillus velezensis T701
This study was done to purify and characterize antitumor lipopeptide from Bacillus strains. Bacillus velezensis strain T701, which was isolated from Chinese sauerkraut, was screened out for its antitumor activity...
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Article
FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction
Fatty acid-binding protein 5 (FABP5) is an important member of the FABP family and plays a vital role in the metabolism of fatty acids. However, few studies have examined the role of FABP5 in pathological card...
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Article
Effects of Extracellular Matrix Softening on Vascular Smooth Muscle Cell Dysfunction
Vascular smooth muscle cells (VSMCs) shift from a physiological contractile phenotype to an adverse proliferative or synthetic state, which is a major event leading to aortic disease. VSMCs are exposed to mult...
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Article
Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism
Normotensive patients with acute pulmonary embolism (APE) are accompanied by heterogeneously adverse events. Responding to tissue injury, lipocalin-2 (LCN-2) is elevated in experimental APE model and associate...
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Article
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis
Pyroptosis is a form of inflammatory cell death that could be driven by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation following my...
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Autophagy and Myocardial Ischemia
Myocardial ischemia and reperfusion cause injury to the heart in myocardial ischemic disease. Both processes increase autophagy. In this chapter, we will provide an overview of the autophagic mechanism caused ...
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Chapter
Autophagy, Myocarditis, and Cardiomyopathy
Direct damage and immune responses after viral infection lead to myocarditis. Autophagy is involved in both viral clearance and replication. In this chapter, we will briefly describe the role of autophagy in v...
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Chapter
Application of Autophagy in Cardiovascular Diseases
Autophagy is closely related to the pathogenesis and progression of cardiovascular diseases. Autophagy may be a therapeutic target for many cardiovascular diseases. In this chapter, we will summarize autophagy...
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Chapter
Autophagy and Hypertension
Hypertension is one of the most common cardiovascular diseases. Sympathetic hyperactivity and renin–angiotensin–aldosterone system activation cause changes in cardiovascular structure and function. Autophagy p...
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Chapter
Autophagy and Heart Failure
Pressure overload can lead to cardiac hypertrophy and heart failure. Autophagic activity could be detected in heart failure patients and animal models. However, the role of autophagy in heart failure is not cl...
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Article
Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a disease characterized by insufficient insulin secretion and glucose metabolic disorder during pregnancy. Tetramethylpyrazine has been reported to inhibit endoplasmic re...
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Reconfiguration of NKT Cell Subset Compartment Is Associated with Plaque Development in Patients with Carotid Artery Stenosis
Accumulating evidence shows that immune cells play an important role in carotid atherosclerotic plaque development. In this study, we assessed the association of 6 different natural killer T (NKT) cell subsets...
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Article
Open AccessResolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats
Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and t...
