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Article
SVEN_5003 is a Major Developmental Regulator in Streptomyces venezuelae
Many regulatory genes that affect cellular development in Streptomyces, such as the canonical bld genes, have already been identified. However, in this study, we identified sven_5003 in Streptomyces venezuelae as...
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Article
Investigations on external separation layer defect of nickel-based superalloy in rotary tube piercing process
A large number of thick-walled tubes of nickel-based superalloy (TWNS) are required in aviation industry and nuclear industry. The rotary tube piercing (RTP) process has great advantages in preparing the seaml...
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Article
Numerical and experimental investigations on Mannesmann effect of nickel-based superalloy
The preparation of nickel-based superalloy tubes by rotary tube piercing (RTP) process is still difficult due to the Mannesmann effect (central cracking phenomenon) has not been clarified. The combinations of ...
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Article
The Response Regulator MacR and its Potential in Improvement of Antibiotic Production in Streptomyces coelicolor
We previously reported that the two-component system MacRS regulates morphogenesis and production of the blue-pigmented antibiotic actinorhodin (ACT) in Streptomyces coelicolor. In this study, the role of MacRS w...
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Article
Open AccessActivation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis
Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT famil...
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Article
A novel XRE family regulator that controls antibiotic production and development in Streptomyces coelicolor
Although the genome of the Streptomyces model strain S. coelicolor was sequenced nearly two decades ago, the function of many annotated genes has not been verified, including that of gene sco1979, which was predi...
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Article
Experimental and numerical analyses of 45 steel during three dimensional severe plastic deformation (3D-SPD)
Due to the limitation of huge forming load, inhomogeneity of plastic deformation, and small volume of deformation region, it is difficult to prepare bulk ultra-fine grains material (UFGM) with industry size by...
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Article
Explorative study of rotary tube piercing process for producing titanium alloy thick-walled tubes with bi-modal microstructure
In order to solve the existing problems in the manufacturing of titanium alloy thick-walled tubes (TATWs), an innovative plastic forming method for the preparation of TATWs using rotary tube piercing (RTP) pro...
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Article
Gene Overexpression in Streptomyces hygroscopicus Associated with DNA Amplification
The genetics of the Streptomyces hygroscopicus strain 10–22 is of interest due to the ability of this strain to produce antifungal compounds. Strain T110 was obtained through insertional mutagenesis of strain 10–...
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Article
A novel exopolysaccharide from deep-sea bacterium Zunongwangia profunda SM-A87: low-cost fermentation, moisture retention, and antioxidant activities
Many marine microorganisms can secrete exopolysaccharides (EPSs) which have important applications in biotechnology. We have purified a novel EPS from deep-sea bacterium Zunongwangia profunda SM-A87, identified i...
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Article
Open AccessDevelopment of a genetic system for the deep-sea psychrophilic bacterium Pseudoalteromonas sp. SM9913
Pseudoalteromonas species are a group of marine gammaproteobacteria frequently found in deep-sea sediments, which may play important roles in deep-sea sediment ecosystem. Although genome sequence analysis of Pse...
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Article
Functional Analysis of the EspR Binding Sites Upstream of espR in Mycobacterium tuberculosis
The ESX-1 secretion system exports substrate proteins into host cells and is crucial for the pathogenesis of Mycobacterium tuberculosis. EspR is one of the characterized transcriptional regulators that modulates ...
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Article
Multilayer clad plate of stainless steel/aluminum/aluminum alloy
The 3, 5, 20 layer clad plate from austenitic stainless steel, pure aluminum and aluminum alloy sheets were fabricated in different ways. The stretch and interface properties were measured. The result shows th...
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Article
Influence of cooling conditions in casting Cu-Ni alloy based on numerical simulation
The most common and serious defect in Cu-Ni alloy casting is porosity. To solve the problem, accurate casting design and proper design of gating system are necessary. It can be predicted and designed by means ...
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Article
Identification of genes necessary for **ggangmycin biosynthesis from Streptomyces hygroscopicus 10-22
A series of large chromosomal deletions in Streptomyces hygroscopicus 10-22 were aligned on the physical map of the wild-type strain and the mutants were assessed for their ability to produce the aminocyclitol an...
