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Article
Open AccessBleomycin induces senescence and repression of DNA repair via downregulation of Rad51
Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a ...
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Article
Open AccessReaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase
Hemiacetal compounds are valuable building blocks in synthetic chemistry, but their enzymatic synthesis is limited and often hindered by the instability of hemiacetals in aqueous environments. Here, we show th...
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Article
Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF-κB Signaling Pathway via Forkhead Box M1
Psoriasis is a chronic inflammatory skin disease associated with multiple comorbidities and complex pathogenesis. Long non-coding RNAs (lncRNAs) play an important regulatory role in many diseases, including ps...
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Article
Boosting xenon adsorption with record capacity in microporous carbon molecular sieves
Xenon/krypton (Xe/Kr) separation is an important task in industry, yet it remains challenging to develop adsorbents with high Xe/Kr selectivity and adsorption capacity of Xe, especially at low partial pressure...
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Article
Open AccessLaparoscopic fixation of biological mesh at hiatus with glue and suture during hiatal hernia repair
Laparoscopic paraesophageal hernia repair is associated with higher recurrence rate. Mesh is used to reduce the recurrence rate. This retrospective study is to review our experience of biological mesh fixed wi...
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Article
Analysis of the Bearing Capacity of Red Clay Foundation Considering Stress Level
Accurately evaluated the bearing capacity characteristic value of red clay is of great important to make use of high strength. Based on analyzing current specifications methods to determine the bearing capacit...
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Chapter and Conference Paper
New Method for Determining Foundation Bearing Capacity Based on Plate Loading Test
A new method for determining the bearing capacity of the foundation based on the plate loading test is proposed in this paper. Assuming that the p (pressure)-s (settlement) curve of the foundation is a hyperbolic...
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Article
Open AccessTargeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
Bacterial CRISPR–Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precl...
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Chapter and Conference Paper
Research on the Application of BIM Technology in Tunnel Project Construction
In order to improve the efficiency of construction and safety management for tunnel works, BIM (Building Information Modeling) is proposed for application. According to the analysis of the characteristics of r...
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Article
The Calculations and Simulation Testing on the Elastic Modulus of Wheat
The elastic modulus (E) of wheat is not only an important parameter in mechanical property of wheat grain, but also is one of the most important parameter for the materials in the analysis three-dimensional model...
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Article
Open AccessAssociation of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis
A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The random-effect model was used. T...
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Protocol
Gene Editing Using ssODNs with Engineered Endonucleases
Gene editing using engineered endonucleases, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISP...
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Article
FEM Simulation of the Hydrogen Diffusion in X80 Pipeline Steel During Stacking for Slow Cooling
The influence of temperature on the hydrogen diffusion behavior in X80 pipeline steel during stacking for slow cooling was studied using electrochemical penetration method, the temperature field and the hydrog...
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Article
Role of regulatory T cells in patients with acute herpes zoster and relationship to postherpetic neuralgia
This study is to analyze distribution of peripheral T cell subsets including regulatory T cells in patients with acute herpes zoster (AHZ) and investigate its relationship to the development of postherpetic ne...
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Article
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases
Single-stranded oligonucleotides are used as donor templates for zinc-finger nucleases to create targeted genomic deletions and mutations in mammalian cell lines.
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Chapter and Conference Paper
A New Bitmap Index and a New Data Cube Compression Technology
This paper introduces a new kind of bitmap index. A tuple in the data cube is mapped to a sequential key (seqkey) determined by its value in each dimension. Furthermore, the quotient bit sequence is constructe...
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Article
A collection of sequenced and mapped Ds transposon insertion sites in Arabidopsis thaliana
Insertional mutagenesis is a powerful tool for generating knockout mutations that facilitate associating biological functions with as yet uncharacterized open reading frames (ORFs) identified by genomic sequen...
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Article
Molecular organization of a gene in barley which encodes a protein similar to aspartic protease and its specific expression in nucellar cells during degeneration
The nucellar cells of barley undergo progressive degeneration after ovule fertilization. This degeneration is a characteristic of programmed cell death. Increasing evidence has indicated that proteases are imp...
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Article
Effect of exogenous plant growth regulators on in vitro seed growth, embryo development, and haploid production in a cross between H. vulgare (L.) and H. bulbosum (L.)
Exogenous plant growth regulators are known to increase the efficiency of interspecific and intergeneric crosses. In vitro floret culture provides a defined system for assessing the importance of various plant...
