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  1. Article

    Open Access

    Wheat Pm55 alleles exhibit distinct interactions with an inhibitor to cause different powdery mildew resistance

    Powdery mildew poses a significant threat to wheat crops worldwide, emphasizing the need for durable disease control strategies. The wheat-Dasypyrum villosum T5AL·5 V#4 S and T5DL·5 V#4 S translocation lines carr...

    Chuntian Lu, Jie Du, Heyu Chen, Shuangjun Gong, Yinyu **… in Nature Communications (2024)

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  2. No Access

    Article

    Photoenzymes for radical C–C coupling

    General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases are repurposed and engineered as highly efficie...

    Rui Guo, Heyu Chen, Yang Yang in Nature Catalysis (2022)

  3. No Access

    Article

    LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis

    Leukocyte immunoglobulin-like receptor B (LILRB), a family of immune checkpoint receptors, contributes to acute myeloid leukemia (AML) development, but the specific mechanisms triggered by activation or inhibi...

    Guo** Wu, Yixiang Xu, Robbie D. Schultz, Heyu Chen, **g**g **e, Mi Deng… in Nature Cancer (2021)

  4. Article

    Correction to: LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Zunling Li, Mi Deng, Fangfang Huang, Changzhu **… in Cellular & Molecular Immunology (2020)

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  5. No Access

    Article

    LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells

    We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular dom...

    Zunling Li, Mi Deng, Fangfang Huang, Changzhu **… in Cellular & Molecular Immunology (2020)

  6. No Access

    Article

    LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

    Immune checkpoint blockade therapy has been successful in treating some types of cancer but has not shown clinical benefits for treating leukaemia1. This result suggests that leukaemia uses unique mechanisms to e...

    Mi Deng, Xun Gui, Jaehyup Kim, Li **e, Weina Chen, Zunling Li, Licai He… in Nature (2018)

  7. Article

    Open Access

    CAMKs support development of acute myeloid leukemia

    We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also ...

    Xunlei Kang, Changhao Cui, Chen Wang, Guo** Wu… in Journal of Hematology & Oncology (2018)

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  8. No Access

    Article

    Malate-Aspartate Shuttle Inhibitor Aminooxyacetate Acid Induces Apoptosis and Impairs Energy Metabolism of Both Resting Microglia and LPS-Activated Microglia

    NADH shuttles mediate the transfer of the reducing equivalents of cytosolic NADH into mitochondria. Cumulating evidence has suggested that malate-aspartate shuttle (MAS), one of the two types of NADH shuttles...

    Heyu Chen, Caixia Wang, Xunbin Wei, **anting Ding, Weihai Ying in Neurochemical Research (2015)

  9. No Access

    Chapter

    Therapeutic Potential of Intranasal Delivery of Drugs and Cells for Stroke and Other Neurological Diseases

    Although numerous studies have suggested the pathological mechanisms underlying stroke-induced brain damage, most clinical trials on the drug treatment of ischemic stroke have been unsuccessful. One of the key...

    Heyu Chen, Caibin Sheng, Weiliang **a, Weihai Ying PhD in Translational Stroke Research (2012)