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  1. No Access

    Article

    AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

    Dietary exposure to aflatoxin B1 (AFB1) is harmful to the health and performance of domestic animals. The hepatic cytochrome P450s (CYPs), CYP1A1 and CYP2A6, are the primary enzymes responsible for the bioactivat...

    Jiang Deng, Jia-Cheng Yang, Yue Feng, Ze-**g Xu, Kamil Kuča… in Science China Life Sciences (2024)

  2. No Access

    Article

    Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress

    Heat stress induces multi-organ damage and serious physiological dysfunction in mammals, and gut bacteria may translocate to extra-intestinal tissues under heat stress pathology. However, whether gut bacteria ...

    Zhang-Chao Deng, Jia-Cheng Yang, Yu-Xuan Huang, Ling Zhao… in Science China Life Sciences (2023)

  3. No Access

    Article

    Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress

    Broiler chicks are fast-growing and susceptible to dietary selenium (Se) deficiency. This study sought to reveal the underlying mechanisms of how Se deficiency induces key organ dysfunctions in broilers. Day-o...

    Ling Zhao, Meng Liu, Hua Sun, Jia-Cheng Yang, Yu-Xuan Huang… in Science China Life Sciences (2023)

  4. No Access

    Article

    YAP inhibitor verteporfin suppresses tumor angiogenesis and overcomes chemoresistance in esophageal squamous cell carcinoma

    Targeting angiogenesis is an attractive strategy for the effective treatment of cancer. This study aimed to investigate the anti-cancer activities of YAP inhibitor verteporfin (VP) in esophageal squamous cell ...

    Xue-Wei Wang, Rong Zhao, Zi-Yi Yang, Ting Li… in Journal of Cancer Research and Clinical On… (2023)