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Article
The Association Between Dietary Magnesium Intake with Chronic Obstructive Pulmonary Disease and Lung Function in US Population: a Cross-sectional Study
Chronic obstructive pulmonary disease (COPD) is now considered among the top three contributors to mortality globally. There is limited understanding surrounding the contribution of magnesium to the progressio...
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Article
The field-scale stabilization remediation and assessment of potential toxic elements based on the multi-source information from a Chinese Pb/Zn smelter contaminated site
Potential toxic elements (PTEs) generally co-existing in soils make a great challenge to the sustainable development and utilization of smelter contaminated sites. This study delved into the pollution characte...
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Article
High-performance sodium storage for cobalt phosphide composite array electrodes
Transition metal phosphides hold great potential as sodium-ion batteries anode materials owing to their high theoretical capacity and modest plateau. However, volume changes and low intrinsic conductivity seri...
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Article
Open AccessCirc-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9
CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...
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Article
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and performance of a DC-targeting virus-like particle pseudotyped w...
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Article
Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions
3,4-Dihydroisoquinoline (DHIQ) is an important precursor used in the production of drugs for treating cancer, HIV, Alzheimer’s disease, etc. Major studies on DHIQ synthesis show low catalytic selectivity due to t...
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Article
AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken
Dietary exposure to aflatoxin B1 (AFB1) is harmful to the health and performance of domestic animals. The hepatic cytochrome P450s (CYPs), CYP1A1 and CYP2A6, are the primary enzymes responsible for the bioactivat...
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Article
Theoretical Exploration of Alloying Effects on Stabilities and Mechanical Properties of γʹ Phase in Novel Co–Al–Nb-Base Superalloys
The new developed γ/γʹ Co–Al–Nb-base alloys show great potentials as high-temperature materials. However, finding appropriate compositions to improve performance of alloys still poses a great challenge to the dev...
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Article
Is postmastectomy radiotherapy necessary for breast cancer patients with clinically node-positive downstaging to ypN0 after neoadjuvant chemotherapy?
The significance of postmastectomy radiotherapy (PMRT) in breast cancer patients who initially have clinically node-positive (cN +) status but achieve downstaging to ypN0 following neoadjuvant chemotherapy (NA...
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Article
Open AccessOral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...
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Article
The catalytic triad of rice NARROW LEAF1 involves H234
NARROW LEAF1 (NAL1) exerts a multifaceted influence on leaf morphology and crop yield. Recent crystal study proposed that histidine 233 (H233) is part of the catalytic triad. Here we report that unlike suggested ...
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Article
Open AccessManufacturing, quality control, and GLP-grade preclinical study of nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles
Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-gr...
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Article
Correction to: Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation
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Article
The longevity evaluation of multi-metal stabilization by MgO in Pb/Zn smelter–contaminated soils
The re-mobilization risks of potentially toxic elements (PTEs) during stabilization deserve to be considered. In this study, artificial simulation evaluation methods based on the environmental stress of freeze...
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Article
Recent advances in bioinspired vision systems with curved imaging structures
Limited by the planar imaging structure, the commercial camera needs to introduce additional optical elements to compensate for the curved focal plane to match the planar image sensor. This results in a comple...
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Article
Open AccessThe Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury
Oxidative stress is a frequently occurring pathophysiological feature of spinal cord injury (SCI) and can result in secondary injury to the spinal cord and skeletal muscle atrophy. Studies have reported that g...
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Article
Open AccessRevolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives
The deployment of imaging examinations has evolved into a robust approach for the diagnosis of lymph node metastasis (LNM). The advancement of technology, coupled with the introduction of innovative imaging dr...
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Article
Semi-automatic proximal humeral trabecular bone density assessment tool: technique application and clinical validation
This study aimed to apply a newly developed semi-automatic phantom-less QCT (PL-QCT) to measure proximal humerus trabecular bone density based on chest CT and verify its accuracy and precision.
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Article
Open AccessPrediction model for EBV infection following HLA haploidentical matched hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for hematological malignancies. However, viral infections, particularly EBV infection, frequently occur following allo-H...
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Article
Open AccessAtomic-scale mechanism of effect of co-separation of elements at interface of ferrite and austenite on Cr-depleted zone of duplex stainless steel
Three-dimensional atom-probe tomography and first-principles calculation combined with density functional theory were used to study the effect of the co-segregation of different elements formed during the soli...
