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Article
A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
The cellular lipidome comprises thousands of unique lipid species. Here, using mass spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and mouse immune cells (ww...
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Article
Open AccessPCPro: a clinically accessible, circulating lipid biomarker signature for poor-prognosis metastatic prostate cancer
Using comprehensive plasma lipidomic profiling from men with metastatic castration-resistant prostate cancer (mCRPC), we have previously identified a poor-prognostic lipid profile associated with shorter overa...
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Article
Open AccessImputation of plasma lipid species to facilitate integration of lipidomic datasets
Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectromet...
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Article
Role of femoral head material on readmission and mortality rates following elective primary total hip arthroplasty in Medicare patients
The role of different femoral head materials for total hip arthroplasty (THA) has been widely studied in the context of wear properties and corrosion. Cobalt chrome (CoCr) femoral heads are commonly used as a ...
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Article
Open AccessMaternal diet quality and associations with plasma lipid profiles and pregnancy-related cardiometabolic health
To assess the relationship of early pregnancy maternal diet quality (DQ) with maternal plasma lipids and indicators of cardiometabolic health, including blood pressure (BP), gestational diabetes mellitus (GDM)...
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Article
Open AccessMetabolic phenoty** of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts
Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all o...
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Article
Open AccessInteractions between the lipidome and genetic and environmental factors in autism
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay...
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Protocol
Comprehensive Targeted Lipidomic Profiling for Research and Clinical Applications
Mass spectrometry remains one of the gold standard approaches in examining the lipidome in biological samples. Recently, advancements in chromatography and mass spectrometry approaches have enabled broad cover...
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Article
Open AccessMulti-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer’s disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in ...
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Article
Open AccessPopulation-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study
Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood.
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Open AccessComprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary arte...
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Article
Open AccessCombined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer
Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with...
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Article
Open AccessHigh-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an accessible, inexpensive therapeutic intervention that can improve mitochondrial bioenergetics and quality of life. B...
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Article
Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer
Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC). The primary aim of the study is to assess the relationship between the plasma lipidome a...
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Article
Open AccessThe placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring
While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, th...
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Article
Open AccessConcordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed a...
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Article
Updated guidelines for intravenous contrast use for CT and MRI
Intravenous (IV) contrast material is used extensively for CT and MRI scans done in emergency departments (ED). Its use is essential to make many critical diagnoses in ED patients. While adverse reactions can ...
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Article
Open AccessSex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differ...
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Article
Disentangling the genetic overlap between cholesterol and suicide risk
Suicide is major public health concern; one million individuals worldwide die by suicide each year of which there are many more attempts. Thus, it is imperative that robust and reliable indicators, or biomarke...
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Article
Open AccessGlucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota
As prednisone and ciclosporin can have immunosuppressive effects and have been considered potential predisposing factors for skin infections, we investigated the impact of these drugs on the diversity of the c...
