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Article
Analysis of Fatty Acid in Biological Samples Using Liquid Chromatography–Quadrupole-Orbitrap Mass Spectrometry Under Parallel Reaction Monitoring Mode
Fatty acids (FAs) are an important class of functional small molecules and participate in a variety of life biological processes. This experiment proposed a liquid chromatography–quadrupole-Qrbitrap mass spect...
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Article
Open AccessHTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosis
Chemotherapy is an important therapuetic strategy for colorectal cancer (CRC), but chemoresistance severely affects its efficacy, and the underlying mechanism has not been fully elucidated. Increasing evidence...
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Article
Heterologous expression of P9 from Akkermansia muciniphila increases the GLP-1 secretion of intestinal L cells
Glucagon-like peptide-1(GLP-1) is an incretin hormone secreted primarily from the intestinal L-cells in response to meals. GLP-1 is a key regulator of energy metabolism and food intake. It has been proven that...
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Article
Continuous sheathless particle separation in viscoelastic fluids with different rheological properties
The separation of particles such as cells and bacteria in viscoelastic fluids has significant applications in biomedical fields. At present, one of the main challenges that limit the application of microfluidi...
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Article
Open AccessDrug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating ...
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Article
Regulate electric double layer for one-step synthesize and modulate the morphology of (oxy)hydroxides
FeOOH have received considerable attention due to their natural abundance and cost-effectiveness. Despite the significant progress achieved, the one-step synthesis of integrated FeOOH is still a major challeng...
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Article
Widespread two-layered melt structure in the asthenosphere
Partial melts in the Earth’s convecting mantle influence its physical and chemical state, particularly the plasticity of the asthenosphere and the dynamics of plate tectonics. Melt compositions change systemat...
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Article
Open AccessEconomic policy uncertainty and cash dividend policy: evidence from China
This paper investigates the impact of economic policy uncertainty (EPU) on the dividend policy of listed companies, alongside its underlying mechanisms. Based on a panel data compilation from 4421 Chinese list...
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Article
Pharmacokinetic Models for Inhaled Fluticasone Propionate and Salmeterol **nafoate to Quantify Batch-to-Batch Variability
Advair Diskus is an essential treatment for asthma and chronic obstructive pulmonary disease. It is a dry powder inhaler with a combination of fluticasone propionate (FP) and salmeterol xinafoate (SX). However...
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Article
Application of Advanced Modeling Approaches Supporting Generic Product Development Under GDUFA for Fiscal Year 2023
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Article
Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis
Acute kidney injury (AKI) is a complication related to important organ dysfunction during autologous stem cell transplantation (ASCT) in light chain (AL) amyloidosis. This study aims to validate the risk facto...
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Article
Open AccessA dataset of storm surge reconstructions in the Western North Pacific using CNN
The relatively short duration of available tide gauge records poses challenges for conducting comprehensive statistical analyses of storm surges in the Western North Pacific. To address this issue, we employ a...
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Article
Exploring the effect of stress arousal on the positive emotional design of multimedia learning
Positive emotional design has been shown to have an important impact on multimedia learning. However, before learning multimedia materials, students may inevitably be stressed by external factors such as learn...
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Article
Synergy of Human-Centered AI and Cyber-Physical-Social Systems for Enhanced Cognitive Situation Awareness: Applications, Challenges and Opportunities
This paper explores the convergence of Human-Centered AI (HCAI) and Cyber-Physical Social Systems (CPSS) in pursuing advanced Cognitive Situation Awareness (CSA). Integrating HCAI principles within CPSS foster...
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Article
Leveraging Modeling and Simulation to Enhance the Efficiency of Bioequivalence Approaches for Generic Drugs: Highlights from the 2023 Generic Drug Science and Research Initiatives Public Workshop
The 2023 Generic Drug Science and Research Initiative Public Workshop organized by the U.S. Food and Drug Administration (FDA) discussed the research needs to improve and enhance bioequivalence (BE) approaches...
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Article
Polysulfide modified PtCu intermetallic nanocatalyst with enrichment realizes efficient electrooxidation ethanol to CO2
The main problem faced by ethanol oxidation reaction (EOR) includes low activity, poor selectivity, and durability. In the study, we found that polysulfide modified on the surface of PtCu intermetallic (IM)/C ...
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Article
Open AccessApplication of Intramedullary Calcar Support Plate and Lateral Locking Plate in Elderly Patients with Neer 3 and 4-Part Fractures of Proximal Humerus Through a Deltoid Splitting Approach
The reduction and fixation of Medial humeral calcar is difficult in the treatment of elderly proximal humerus Neer 3 and 4-part fractures with a single lateral locking plate. Our study investigated the efficac...
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Article
Study on the Fabrication and Grinding Performance of the Self-sharpening Cr2O3 Gel Abrasive Tool
This paper proposes a chromium oxide (Cr2O3) gel abrasive tool with the coated aluminum nitride (AlN) powder to give the tool with self-sharpening ability. The SiO2/AlN powder (S/A powder) is prepared through the...
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Article
Open AccessQSAR analysis of VEGFR-2 inhibitors based on machine learning, Topomer CoMFA and molecule docking
VEGFR-2 kinase inhibitors are clinically approved drugs that can effectively target cancer angiogenesis. However, such inhibitors have adverse effects such as skin toxicity, gastrointestinal reactions and hepa...
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Article
Open AccessValvar bypass surgery to ameliorate persistent lower limb edema caused by post-thrombotic syndrome: a case report and literature review
Obstruction and/or reflux compromise during venous emptying can facilitate different pathophysiologies in chronic venous insufficiency (CVI). We present a patient with persistent lower limb CVI edema caused by...
