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Article
Open AccessDiagnosis and treatment of the Ehlers-Danlos syndromes in China: synopsis of the first guidelines
The Ehlers-Danlos syndromes (EDS) are a group of rare hereditary connective tissue disorders. EDS is clinically and genetically heterogeneous and usually involves multiple systems. There are 14 subtypes of EDS...
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Article
Visual outcomes and prognostic factors of early pars plana vitrectomy for open globe injury
To identify the clinical features and outcomes of early vitrectomy in patients with open globe injury (OGI) and the prognostic factors for visual outcome.
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Article
“Exercising like my sporty idol”: sporty prototype perceptions associated with adolescents’ physical activity in an integrative behavioral prediction model
Lack of physical activity (PA) has become an increasingly worrying public health issue among Chinese adolescents. Drawing upon an integrative model of behavioral prediction, this study investigated how adolesc...
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Article
Deciphering and predicting changes in antibiotic resistance genes during pig manure aerobic composting via machine learning model
Livestock manure is one of the most important pools of antibiotic resistance genes (ARGs) in the environment. Aerobic composting can effectively reduce the spread of antibiotic resistance risk in livestock man...
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Article
Sub-region aware retrieval-based network with multimodal prior knowledge guidance for microvascular invasion prediction in PET/CT imaging
Accurate preoperative microvascular invasion (MVI) prediction using PET/CT imaging is important for guiding surgical plans and treatment strategies for hepatocellular carcinoma (HCC) patients. Deep learning (D...
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Article
Open AccessCirc_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis
The long-term high-fat diet (HFD) can cause myocardial lipotoxicity, which is characterized pathologically by myocardial hypertrophy, fibrosis, and remodeling and clinically by cardiac dysfunction and heart fa...
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Article
Vital residues-orientated rational design of butenolide inhibitors targeting Of ChtI
An effective approach for discovering small molecular inhibitors is the residues-oriented strategy based on enzyme analysis. In this study, we employed a rational approach to design and synthesize a library of...
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Article
Mechanical Property Degradation and Prediction Model of Red Sandstone Under Action of Dry–Wet Cycles in Acid Environment
To investigate the long-term degradation in rock mechanical properties under the coupling effect of dry–wet cycles and acid solutions, the physical test, uniaxial compression test, and scanning electron micros...
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Article
Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway
Chemoresistance is a significant barrier to effective cancer treatment. Potential mechanisms for chemoresistance include reactive oxygen species (ROS) accumulation and expression of chemoresistance-promoting g...
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Article
Open AccessACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity
The appropriate transcriptional activity of PPARγ is indispensable for controlling inflammation, tumor and obesity. Therefore, the identification of key switch that couples PPARγ activation with degradation to...
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Article
Degradation of wild fruit forests created less diverse and diffuse bacterial communities decreased bacterial diversity, enhanced fungal pathogens and altered microbial assembly in the Tianshan Mountain, China
Wild fruit forests are vital reservoirs of germplasm genetic and biodiversity. Unfortunately, wild fruit forests of Central Asia are in the decline due to fungal disease and insect pest outbreaks. A health soi...
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Article
LncRNA DGUOK-AS1 Promotes Cell Progression in Lung Squamous Cell Carcinoma by Regulation of miR-653-5p/SLC6A15 Axis
Long noncoding RNA (lncRNA) plays a key role in regulating cancer development. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been reported as a promoter in tumor. The work was designed to furthe...
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Article
Leveraging facial expressions as emotional context in image captioning
Image captioning has emerged as a prominent approach for generating verbal descriptions of images that humans can read and understand. Numerous techniques and models in this domain have predominantly focused o...
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Article
Open AccessUnraveling the genetic architecture of congenital vertebral malformation with reference to the develo** spine
Congenital vertebral malformation, affecting 0.13–0.50 per 1000 live births, has an immense locus heterogeneity and complex genetic architecture. In this study, we analyze exome/genome sequencing data from 873...
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Article
Open AccessCorrection: c-Myc-activated long non-coding RNA LINC01050 promotes gastric cancer growth and metastasis by sponging miR-7161-3p to regulate SPZ1 expression
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Article
Open AccessSkeletal muscle extramedullary plasmacytoma transformed into plasmablastic plasmacytoma: a case report
Extramedullary plasmacytoma (EMP) is a rare plasma cell malignancy, especially when the tumor originates in skeletal muscle. Plasmablastic plasmacytoma is an anaplastic round cell tumor with highly malignancy ...
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Article
Pharmacokinetics, Pharmacodynamics, and Safety of Single Dose HSK7653 Tablets in Chinese Subjects with Normal or Impaired Renal Function
HSK7653 is a novel, ultralong-acting dipeptidyl peptidase-4 (DPP-4) inhibitor, promising for type 2 diabetes mellitus with a dosing regimen of once every 2 weeks. This trial investigates the pharmacokinetics (...
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Article
Comparative Proteomics Analysis Reveals the Molecular Mechanisms Underlying the Accumulation Difference of Bioactive Constituents in Taxilli Herba from Two Hosts
Taxilli Herba (TH) is famous for semi-parasitic feature, with hundreds of host species. The content of bioactive constituents varies in TH from different hosts. To gain insight into the molecular mechanisms of...
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Chapter and Conference Paper
Zero-Shot Action Recognition with ChatGPT-Based Instruction
As deep learning continues to evolve, datasets are becoming increasingly larger, leading to higher costs for manual labeling. Zero-shot learning eliminates the need for substantial labor costs to label trainin...
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Chapter and Conference Paper
Study on Influence Factors of Sealing Pipe Thread Connection
With the development of scientific and technological innovation, pipe threads are more and more widely used in industry, especially in the field of hydraulic manifolds. This paper introduces the structure form...
