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Open AccessThe basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation
Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear learning,...
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Article
Open AccessA novel type-II–II heterojunction for photocatalytic degradation of LEV based on the built-in electric field: carrier transfer mechanism and DFT calculation
Heterojunctions play a crucial role in improving the absorption of visible light and performance of photocatalysts for organic contaminants degradation in water. In this work, a novel type-II–II Ag2CO3/Bi2WO6 (AB...
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Exploring the psychological dynamics of the flow experience in tourism: a comparative study of the pre- and post-COVID-19 pandemic periods
As a positive psychological resource, the concept of the flow experience has attracted significant attention across various domains. However, there remain gaps in our understanding of the underlying psychologi...
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Article
Human Umbilical Cord Mesenchymal Stem Cells Promote Anti-Inflammation and Angiogenesis by Targeting Macrophages in a Rat Uterine Scar Model
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have demonstrated efficacy in repairing uterine scars, although the underlying mechanisms remain unclear.
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Open AccessVisualizing a single wavefront dislocation induced by orbital angular momentum in graphene
Phase singularities are phase-indeterminate points where wave amplitudes are zero, which manifest as phase vertices or wavefront dislocations. In the realm of optical and electron beams, the phase singularity ...
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Systemic glucocorticoids link to long-term microvascular injury in COVID-19
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Open AccessGenome-wide identification and evolutionary analysis of the NRAMP gene family in the AC genomes of Brassica species
Brassica napus, a hybrid resulting from the crossing of Brassica rapa and Brassica oleracea, is one of the most important oil crops. Despite its significance, B. napus productivity faces substantial challenges du...
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Article
Integrated Multi-Spectroscopy and Molecular Dynamics Simulations to Explore the Interaction Mechanism of Phenolic Compounds and Sea Bass Myofibrillar Protein
Polyphenol compounds can modify myofibrillar proteins to improve the quality of fish and surimi. Nevertheless, research into the precise mechanisms of interaction between phenolic substances and sea bass myofi...
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Open AccessLong-term follow-up after the treatment of impacted canines in the maxilla causing severe root resorption of the lateral incisors: two case reports
Root resorption of adjacent teeth due to impacted canines is common, and orthodontic treatment often leads to secondary resorption or even loss of adjacent roots. Clinical reports of long-term stability after ...
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Article
A terminal trend model for longitudinal medical cost data and survival
A joint modeling approach on survival and longitudinal data has proven to be valuable in end of life applications, especially when there is a strong relationship between the longitudinal measurements and survi...
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Article
Open AccessRimegepant orally disintegrating tablet 75 mg for acute treatment of migraine in adults from China: a subgroup analysis of a double-blind, randomized, placebo-controlled, phase 3 clinical trial
Rimegepant orally disintegrating tablet (ODT), an oral small-molecule calcitonin gene-related peptide receptor antagonist, is indicated for acute and preventive treatment of migraine in the United States and ...
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Article
Open AccessHuman mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway
Chemotherapy exposure has become a main cause of premature ovarian insufficiency (POI). This study aimed to evaluate the role and molecular mechanism of human umbilical cord mesenchymal stem cell-derived exoso...
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Article
The prognosis and treatment of newly diagnosed bone metastasis of head and neck squamous cell cancer: an analysis of racial disparity
There is a lack of research investigating racial disparity in newly diagnosed head and neck squamous cell carcinoma with isolated bone metastases (HNSCC-BM). This study aims to investigate the clinical charact...
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Blood pressure variability and outcome in atherosclerosis versus cardioembolism cerebral large vessel occlusion after successful thrombectomy
Higher blood pressure variability (BPV) has been proven associated with worse functional outcome after endovascular treatment (EVT). However, this association is not established according to different stroke e...
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Article
Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study
Both metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent in major depressive disorder (MDD) patients. However, their relationship in this population remains unknown. The study assessed...
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Article
Open AccessPhotoheterotroph improved the growth and nutrient levels of Chlorella vulgaris and the related molecular mechanism
Microalgae are rich in fatty acids, proteins, and other nutrients, which have gained the general attention of researchers all over the world. For the development of Chlorella vulgaris in food and feed industry, t...
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Article
Ethylene may be the Key Factor Leading to the Homologous Transformation of Stamens into Pistils in Three-Pistil Wheat
Previous studies have shown that ethylene levels in flower buds are key to sex determination in plants. However, the roles of ethylene in wheat flower development are poorly understood. In this study, pistillo...
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Article
Is thyroid function associated with polycystic ovary syndrome? A bidirectional Mendelian randomization study
Some observational studies have suggested the association between thyroid function and polycystic ovary syndrome (PCOS). However, it remains to be determined whether these associations are causal or not. The a...
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Article
Establishment of NaLuF4:15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy
X-ray excited photodynamic therapy (X-PDT) is the bravo answer of photodynamic therapy (PDT) for deep-seated tumors, as it employs X-ray as the irradiation source to overcome the limitation of light penetratio...
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Article
27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
Trophoblast cell syncytialization is essential for placental and fetal development. Abnormal trophoblast cell fusion leads to pregnancy pathologies, such as preeclampsia (PE), intrauterine growth restriction (...
