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  1. Article

    Open Access

    Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration

    Chemogenetic approaches employing ligand-gated ion channels are advantageous regarding manipulation of target neuronal population functions independently of endogenous second messenger pathways. Among them, Io...

    Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi… in Communications Biology (2024)

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  2. Article

    Open Access

    Conjunctive encoding of exploratory intentions and spatial information in the hippocampus

    The hippocampus creates a cognitive map of the external environment by encoding spatial and self-motion-related information. However, it is unclear whether hippocampal neurons could also incorporate internal c...

    Yi-Fan Zeng, Ke-**n Yang, Yilong Cui, **ao-Na Zhu, Rui Li… in Nature Communications (2024)

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  3. No Access

    Article

    [18F]DPA-714 PET imaging for the quantitative evaluation of early spatiotemporal changes of neuroinflammation in rat brain following status epilepticus

    Most antiepileptic drug therapies are symptomatic and adversely suppress normal brain function by nonspecific inhibition of neuronal activity. In recent times, growing evidence has suggested that neuroinflamma...

    Ken-ichi Kaneko, Satsuki Irie, Aya Mawatari… in European Journal of Nuclear Medicine and M… (2022)

  4. Chapter and Conference Paper

    Integrated Imaging on Fatigue and Chronic Fatigue

    The neural and molecular mechanisms of fatigue and chronic fatigue are not fully understood, although our previous studies revealed the involvement of dysfunction of autonomic nervous system, and deterioration...

    Yasuyoshi Watanabe, Masaaki Tanaka, Akira Ishii, Kei Mizuno… in Make Life Visible (2020)

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  5. No Access

    Article

    Exploration of Antiemetics for Osteoporosis Therapy-Induced Nausea and Vomiting Using PET Molecular Imaging Analysis to Gastrointestinal Pharmacokinetics

    To select appropriate antiemetics relieving teriparatide-induced nausea and vomiting during osteoporosis treatment using PET molecular imaging and pharmacokinetic analysis.

    Tomotaka Shingaki, Yumiko Katayama, Takayoshi Nakaoka… in Pharmaceutical Research (2016)

  6. No Access

    Article

    Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse

    To evaluate the function of multidrug and toxin extrusion proteins (MATEs) using 11C-labeled metformin ([11C]metformin) by positron emission tomography (PET).

    Tomotaka Shingaki, W. Ewan Hume, Tadayuki Takashima… in Pharmaceutical Research (2015)

  7. No Access

    Article

    Role of cortical spreading depression in the pathophysiology of migraine

    A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-pro...

    Yilong Cui, Yosky Kataoka, Yasuyoshi Watanabe in Neuroscience Bulletin (2014)

  8. No Access

    Article

    Perineuronal germinal cells in the rat cerebral cortex

    The generation and renewal of cells in the adult mammalian central nervous system maintains brain functions, including plasticity. Even in the cerebral cortex of adult mammals, glial cells are thought to be re...

    Yosky Kataoka, Yasuhisa Tamura, Yasuharu Takamori… in Medical Molecular Morphology (2006)