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Article
Open AccessTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell...
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Article
N-3 PUFA supplementation alleviates anxiety symptoms by manipulating erythrocyte fatty acid levels in depression
Major depressive disorder (MDD) is frequently accompanied by the symptoms of clinical anxiety. Since our previous research has found that n-3 PUFA supplementation alleviates anxiety in MDD, this study was aime...
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Article
Open AccessStrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records
Determining acute ischemic stroke (AIS) etiology is fundamental to secondary stroke prevention efforts but can be diagnostically challenging. We trained and validated an automated classification tool, StrokeClass...
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Article
Preparation and Performance of MWNTs/ Epoxy Resins Composites
In this work, a series of functionalized MWNTs/EP composites were fabricated by epoxy resins (EP) and functionalized multi-walled carbon nanotubes (MWNTs). The dispersion of MWNTs in the EP matrix, through dif...
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Article
Open AccessBicontinuous RuO2 nanoreactors for acidic water oxidation
Improving activity and stability of Ruthenium (Ru)-based catalysts in acidic environments is eager to replace more expensive Iridium (Ir)-based materials as practical anode catalyst for proton-exchange membran...
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Article
Open AccessMulti-view Self-supervised Learning and Multi-scale Feature Fusion for Automatic Speech Recognition
To address the challenges of the poor representation capability and low data utilization rate of end-to-end speech recognition models in deep learning, this study proposes an end-to-end speech recognition mode...
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Article
Open AccessDisruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia
Preeclampsia, one of the most lethal pregnancy-related diseases, is associated with the disruption of uterine spiral artery remodeling during placentation. However, the early molecular events leading to preecl...
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Article
Optimizing predictions: improved performance of preoperative gadobenate-enhanced MRI hepatobiliary phase features in predicting vessels encapsulating tumor clusters in hepatocellular carcinoma—a multicenter study
Vessels Encapsulating Tumor Clusters (VETC) are now recognized as independent indicators of recurrence and overall survival in hepatocellular carcinoma (HCC) patients. However, there has been limited investiga...
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Article
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has t...
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Article
Machine learning-assisted sparse observation assimilation for real-time aerodynamic field perception
Accurate aerodynamic distribution perception and real-time flight state evaluation are crucial for flight safety, e.g., stall detection. However, the observations are usually sparse due to limitations in senso...
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Article
Effects of different water and nitrogen treatments on greenhouse tomato yield, water use efficiency, and physiological responses
This study aimed to explore how the yield, water use efficiency (WUE), and physiological characteristics of greenhouse-cultivated tomatoes in Northeast China respond to different water and nitrogen treatments ...
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Article
Open AccessGlis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease
Mouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact primary cilia are required for cyst growth following the inactivation of polycystin-1. The signaling pathways underlying th...
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Article
Open AccessComparison of two swept-source optical coherence tomography devices, a Scheimpflug camera system and a ray-tracing aberrometer in the measurement of corneal power in patients with cataract
To assess the differences and similarities in the corneal curvature obtained by two swept-source optical coherence tomography (SS-OCT) devices, Scheimpflug imaging system and one ray tracing aberrometer in pat...
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Article
A Novel Impedance Control Based on Equivalent Stiffness for Hydraulic Single-leg Robot
This paper presents a proposed strategy for improving the position-tracking accuracy of force-based impedance control in hydraulic single-leg robots. Initially, the mechanical structure and drive system of the...
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Article
Formation of ZnSe magic-size clusters displaying optical absorption doublets from prenucleation clusters
The formation pathway of colloidal semiconductor ZnSe magic-size clusters (MSCs) in a reaction that display an optical absorption doublet remains poorly understood. The reaction of Zn(OAc)2/OLA (made from zinc ac...
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Article
Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
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Article
Open AccessFlexible TAM requirement of TnpB enables efficient single-nucleotide editing with expanded targeting scope
TnpBs encoded by the IS200/IS605 family transposon are among the most abundant prokaryotic proteins from which type V CRISPR-Cas nucleases may have evolved. Since bacterial TnpBs can be programmed for RNA-guid...
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Article
Effect of oxygen concentration on the heat release behaviour of bituminous coal over the complete spontaneous combustion process
The effect of different oxygen concentration conditions on the heat release behaviour of bituminous coal during spontaneous combustion was investigated. Thermal analysis experiments were conducted using differ...
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Article
Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as late-onset hypogonadism (LOH), remain incompletely understood....
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Article
Open AccessFBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung a...
