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Article
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely unexplored. Here, we analyzed the...
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Article
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
The blood–brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2–4. However, the m...
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Article
Open AccessThe PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation
CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of p...
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Article
Open AccessPrecise prediction of phase-separation key residues by machine learning
Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most...
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Article
Open AccessTransurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: a systematic review and meta-analysis
The efficacy of surgical treatment for benign prostatic hyperplasia (BPH) patients with detrusor underactivity (DU) remains controversial.
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Article
Robust, breathable, and chemical-resistant polytetrafluoroethylene (PTFE) films achieved by novel in-situ fibrillation strategy for high-performance triboelectric nanogenerators
In the era of advanced wearable electronic devices, the triboelectric nanogenerators (TENGs) as energy harvesting and self-powered sensing units hold great promise. Selecting appropriate triboelectric material...
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Article
Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity
Malignant obstruction makes gallbladder cancer have a high mortality rate. Nickel–titanium alloy (nitinol) stents are commonly used as a local intervention to maximize patient survival time, but the stents lac...
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Article
Open AccessAPRE: Annotation-Aware Prompt-Tuning for Relation Extraction
Prompt-tuning has been successfully applied to support classification tasks in natural language processing and has achieved promising performance. The main characteristic of prompt-tuning based classification ...
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Article
Multifunctional and Reconfigurable Electronic Fabrics Assisted by Artificial Intelligence for Human Augmentation
Noninvasive human augmentation, namely a desirable approach for enhancing the quality of life, can be achieved through wearable electronic devices that interact with the external environment. Wearable electron...
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Article
Size-dependent effect of the flexoelectronics in a composite beam
In this paper, a sandwich composite structure consisting of two piezoelectric layers and a flexoelectric semiconductor layer is proposed, where piezoelectric layers are poled in opposite direction, either tail...
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Article
Application of new optical imaging equipment based on deep learning in kidney tumor image segmentation and recognition
The precise classification of kidneys and kidney tumors is of great guiding significance for the diagnosis and surgical planning of clinical doctors. Artificial segmentation of kidneys and renal tumors not onl...
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Article
Orange red Ca9Sc(PO4)7: Sm3+ phosphor with excellent thermal stability for solid state lighting
In this study, a series of Ca9Sc(PO4)7: Sm3+ (CSP: Sm3+) orange-red phosphors were synthesized by the conventional solid-phase method, and their crystal structure, luminescent properties, decay lifetimes and ther...
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Chapter and Conference Paper
Research and Practice on Sand Control Completion Technology for CO2 Heavy Oil Huff and Puff Sand Production Wells in Bohai Bay Y Oilfield
In response to the problem of corrosion and sand production environment during the carbon dioxide huff and puff development process of loose sandstone heavy oil reservoirs in Bohai Bay Y Oilfield, which leads ...
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Chapter and Conference Paper
ACE-BERT: Adversarial Cross-Modal Enhanced BERT for E-Commerce Retrieval
Nowadays on E-commerce platforms, products usually contain multi-modal descriptions. To search related products from user-generated texture queries, most previous works learn the multi-modal retrieval models b...
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Article
Spatial distribution characteristics of denitrification functional genes and the environmental drivers in Liaohe estuary wetland
Genes nirS, nirK, and nosZ are specific for the denitrification process, which is associated with greenhouse gas N2O emission. The abundances and diversities of community containing these three genes are usually ...
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Article
Research progress on antibacterial activity of medical titanium alloy implant materials
Titanium and its alloys are the preferred materials for medical implants. However, easy infection is a fatal shortcoming of Ti implants. Fortunately, the ongoing development of antibacterial implant materials ...
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Article
Least squares estimation for a class of uncertain Vasicek model and its application to interest rates
This paper addresses statistical inference in uncertain differential equations, focusing on parameter estimation for a class of uncertain Vasicek model with a small dispersion coefficient from discrete observa...
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Article
USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail
Choroidal melanoma (CM) is an intraocular tumor that arises from melanocytes. While ubiquitin-specific protease 2 (USP2) modulates the progression of numerous diseases, its role in CM is not known. This study ...
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Article
Simultaneous profiling of chromatin architecture and transcription in single cells
The three-dimensional structure of chromatin plays a crucial role in development and disease, both of which are associated with transcriptional changes. However, given the heterogeneity in single-cell chromati...
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Article
Open AccessSYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility
The cytoplasmic droplet is a conserved dilated area of cytoplasm situated at the neck of the sperm flagellum. Viewed as residual cytoplasm inherited from late spermatids, the cytoplasmic droplet contains numer...
