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Article
Open AccessA real-world pharmacovigilance study of FDA adverse event reporting system events for Capmatinib
Capmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study eval...
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Article
Comparative Study of Microbial Contact Effect on Complex Copper Sulfide Concentrate Containing Enargite, Covellite and Digenite
In this study, the contact effects between mesophile bacteria and minerals were observed to enhance the bioleaching kinetics, which demonstrated that the adsorption of bacteria to mineral surfaces could improv...
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Article
Open AccessExperimental study on flow characteristics of jet ventilation in crossflow in confined mine spaces
The increasing depth of mine excavation presents greater challenges in mine ventilation and in managing cooling energy consumption. Therefore, there is an urgent need for comprehensive research on jet ventilat...
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Article
Study and application of deeply optimized neural network in roof stability evaluation
Deep coal seam mining causes instability and collapse of coal seam roof frequently, which seriously affects the safety production and threatens the personal safety of underground personnel. In order to evaluat...
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Article
Open AccessThe endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and mo...
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Article
Open AccessAssociation of systemic immunity-inflammation index with metabolic syndrome in U.S. adult: a cross-sectional study
Metabolic syndrome (MetS) is a pathological condition characterized by the abnormal clustering of several metabolic components and has become a major public health concern. We aim to investigate the potential ...
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Chapter and Conference Paper
3D-RBSM: A New Mesoscale Discrete Approach for FRP-Concrete Interfacial Simulation
A reliable numerical simulation is one of the major challenges in analyzing the bond behavior between fiber reinforced polymer (FRP) sheets/laminates and concrete. This paper presents a recent developed ration...
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Chapter and Conference Paper
An Improved Fast All-Sky Star Identification Based on the Polygon Algorithm
The star identification is a prerequisite for the in-orbit calibration of some space cameras. This paper proposes an improved polygonal fast all-sky star identification method with the unstable internal and ex...
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Article
Negative mixing enthalpy solid solutions deliver high strength and ductility
Body-centred cubic refractory multi-principal element alloys (MPEAs), with several refractory metal elements as constituents and featuring a yield strength greater than one gigapascal, are promising materials ...
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Chapter
Fringe Projection Profilometry
Driven by industrial needs, medical applications, and entertainment, three-dimensional (3D) surface measurement techniques have received extensive studies. As one of the most popular techniques for non-contact...
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Article
Open AccessAnimal models of acute exacerbation of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience acute exacerbations (AE), which result in severe lung damage...
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Article
Identification and Characterization of Two Novel Extracellular β-Glucanases from Chaetomium globosum against Fusarium sporotrichioides
Chaetomium globosum can inhibit the growth of fusarium by means of their extracellular proteins. Two novel β-glucanases, designated Cgglu17A and Cgglu16B, were separated from the supernatant of C. globosum W7 an...
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Article
Open AccessIntegrative Analysis of Inflammatory Response-Related Gene for Predicting Prognosis and Immunotherapy in Glioma
Inflammatory response plays a crucial role in the development and progression of gliomas. Whereas the prognostic esteem of inflammatory response-related genes has never been comprehensively explored in glioma,...
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Article
Open AccessGuided construction of single cell reference for human and mouse lung
Accurate cell type identification is a key and rate-limiting step in single-cell data analysis. Single-cell references with comprehensive cell types, reproducible and functionally validated cell identities, an...
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Article
Open AccessRelationship between alexithymia, loneliness, resilience and non-suicidal self-injury in adolescents with depression: a multi-center study
Non-suicidal self-injury (NSSI) behaviors are prevalent in adolescents and have adverse effects on physical and mental health. However, little is known about the relationship between NSSI and alexithymia, or t...
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Article
Droplet microarray platforms for high-throughput drug screening
High-throughput screening platforms are fundamental for the rapid and efficient processing of large amounts of experimental data. Parallelization and miniaturization of experiments are important for improving ...
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Article
Open AccessEpigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1
Ferroptosis has been linked to tumor progression and resistance to antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of tumor cells, while the functio...
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Article
Rock Adaptability of TBM Variable Cross-section Cutter Ring Based on Finite Element Simulation
A cutter ring is a consumable tool used by a tunnel boring machine (TBM) to break rock, affecting the cost and time limit of tunnel engineering. In this paper, based on the working principle of the cutter ring...
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Article
Deficiency of HtrA3 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via TGF-β1/Smad Signaling Pathway
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by excessive extracellular matrix deposition. No effective treatments are currently available for IPF. High-...
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Article
Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging
Molecular classification has transformed the management of brain tumors by enabling more accurate prognostication and personalized treatment. However, timely molecular diagnostic testing for patients with brai...
