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Article
Open AccessNatural and engineered enzymes for polyester degradation: a review
Plastic pollution is becoming a major health issue due to the recent discovery of microplastics and nanoplastics in living organisms and the environment, calling for advanced technologies to remove plastic was...
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Article
Open AccessThe structural and functional investigation into an unusual nitrile synthase
The biosynthesis of neurotoxin aetokthonotoxin (AETX) that features a unique structure of pentabrominated biindole nitrile involves a first-of-its-kind nitrile synthase termed AetD, an enzyme that shares very ...
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Article
Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
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Article
Open AccessA single preoperative low-dose dexamethasone may reduce the incidence and severity of postoperative delirium in the geriatric intertrochanteric fracture patients with internal fixation surgery: an exploratory analysis of a randomized, placebo-controlled trial
Postoperative delirium (POD) is a common complication along with poor prognosis in geriatric intertrochanteric fracture (ITF) patients. However, the prevention and treatment of POD remain unclear. Previous stu...
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Article
Open AccessFunctional tailoring of a PET hydrolytic enzyme expressed in Pichia pastoris
Using enzymes to hydrolyze and recycle poly(ethylene terephthalate) (PET) is an attractive eco-friendly approach to manage the ever-increasing PET wastes, while one major challenge to realize the commercial ap...
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Article
Open AccessComplete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases
Poly(butylene adipate-co-terephthalate) (PBAT), a polyester made of terephthalic acid (TPA), 1,4-butanediol, and adipic acid, is extensively utilized in plastic production and has accumulated globally as envir...
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Article
Open AccessStandardized Tip-Apex Distance (STAD): a modified individualized measurement of cephalic fixator position based on its own femoral head diameter in geriatric intertrochanteric fractures with internal fixation
To design a standardized Tip-Apex Distance (STAD) and analyze the clinical significance of STAD in predicting cut-out in geriatric intertrochanteric fractures with internal fixation.
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Article
Open AccessThe correlation between cutout and eccentric distance (ED) of the cephalic fixator tip in geriatric intertrochanteric fractures with internal fixation
The location of cephalic fixator tip with different eccentric distance (ED) should have different risks of cutout. This study aims to evaluate the cephalic fixator tip position by measuring ED of the cephalic ...
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Article
Open AccessRisk factors for cut-outs in geriatric intertrochanteric fractures with cephalomedullary nailing after obtaining acceptable reduction: a case–control study
It is irresponsible if we disregard reduction quality to talk about cut-outs in intertrochanteric fractures (ITF) with internal fixation. The aim of this study is to analyze the risk-factors for cut-outs in ge...
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Article
General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis
Poly(ethylene terephthalate) (PET) is the most abundant polyester plastic and a major contributor to plastic pollution. IsPETase, from the PET-assimilating bacterium Ideonella sakaiensis, is a unique PET-hydrolyt...
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Article
Open AccessStructural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase
Cytochrome P450 monooxygenases are versatile heme-thiolate enzymes that catalyze a wide range of reactions. Self-sufficient cytochrome P450 enzymes contain the redox partners in a single polypeptide chain. Her...
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Article
Higher order asymptotic behaviour of partial maxima of random sample from generalized Maxwell distribution under power normalization
In this article, the higher order asymptotic expansions of cumulative distribution function and probability density function of extremes for generalized Maxwell distribution are established under nonlinear nor...
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Article
Open AccessStructural insight into catalytic mechanism of PET hydrolase
PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a nove...
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Article
Improving the catalytic performance of a GH11 xylanase by rational protein engineering
XynCDBFV from Neocallimastix patriciarum is among the most effective xylanases and holds great potentials in a wide variety of industrial applications. In the present study, several active site residues were modi...
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Article
Arsenic trioxide transarterial chemoembolization with and without additional intravenous administration of arsenic trioxide in unresectable hepatocellular carcinoma with lung metastasis: a single-blind, randomized trial
To evaluate the efficacy and safety of arsenic trioxide transarterial chemoembolization and intravenous administration in unresectable hepatocellular carcinoma with lung metastasis.
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The Implication of City Form Transformation in Rongcheng Area of Jieyang City
This paper focuses on the form transformation of Rongcheng area of Jieyang city form the time dimension during three specific periods: the Qing Dynasty, the Republic era, and today. And form the space dimensio...
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Article
Genetic variants in the KDR gene is associated with the prognosis of transarterial chemoembolization treated hepatocellular carcinoma
Kinase insert domain receptor (KDR) is the principal receptor that promotes the proangiogenic action of vascular endothelial growth factor and is involved in the tumorigenesis and progression of many malignanc...
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Article
Retraction Note to: Clinical value of circulating tumor cells for the prognosis of postoperative transarterial chemoembolization therapy
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The relationship of kinase insert domain receptor gene polymorphisms and clinical outcome in advanced hepatocellular carcinoma patients treated with sorafenib
Kinase insert domain receptor (KDR) is the principal receptor that promotes the pro-angiogenic action of vascular endothelial growth factor and has been the principal target of anti-angiogenic therapies. Our a...
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Article
RETRACTED ARTICLE: Clinical value of circulating tumor cells for the prognosis of postoperative transarterial chemoembolization therapy
The aim of this study was to clarify circulating tumor cells (CTCs) count could reflect the effect of postoperative transarterial chemoembolization therapy. A single-blind, two-parallel group, randomized tria...
