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Article
Open AccessAnalysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease
Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer’s disease (AD). However, the precise role of necroptosis and its correlation with immune cell infiltration in AD...
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Article
Open AccessIdentification of metabolism-related subtypes and feature genes in Alzheimer’s disease
Owing to the heterogeneity of Alzheimer's disease (AD), its pathogenic mechanisms are yet to be fully elucidated. Evidence suggests an important role of metabolism in the pathophysiology of AD. Herein, we iden...
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Reference Work Entry In depth
SDG 8, Decent Work, and Post-Covid Recovery: Policy Implications, Challenges, and Opportunities in the UK
Promoting decent work is at the heart of the United Nations’ eighth Sustainable Development Goal (SDG), which sets the access to decent work as an important priority for both employers and policy makers to imp...
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Living Reference Work Entry In depth
SDG 8, Decent Work, and Post-Covid Recovery: Policy Implications, Challenges, and Opportunities in the UK
Promoting decent work is at the heart of the United Nations’ eighth Sustainable Development Goal (SDG), which sets the access to decent work as an important priority for both employers and policy makers to imp...
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Chapter and Conference Paper
Research on Data Acquisition Algorithm Based on ZYNQ Biometric Signal
Under the irradiation of laser, biological particles emit fluorescence and scattered light. The spectral signals composed of fluorescence and scattered light can be used to classify and recognize biological pa...
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Article
Open AccessCharacteristic of Parkinson’s disease with severe COVID-19: a study of 10 cases from Wuhan
Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with seve...
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Reference Work Entry In depth
Decent Work in China
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Reference Work Entry In depth
Foreign Direct Investment and Decent Work in Sub-Saharan Africa
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Article
Open AccessIncreasing endogenous activity of NMDARs on GABAergic neurons increases inhibition, alters sensory processing and prevents noise-induced tinnitus
Selective enhancement of GABAergic inhibition is thought to impact many vital brain functions and interferes with the genesis and/or progression of numerous brain disorders. Here, we show that selectively incr...
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Article
Initiation of Parkinson’s disease from gut to brain by δ-secretase
Lewy pathology, composed of α-Synuclein (α-Syn) inclusions, a hallmark of Parkinson’s disease (PD), progressively spreads from the enteric nervous system (ENS) to the central nervous system (CNS). However, it ...
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Living Reference Work Entry In depth
Foreign Direct Investment and Decent Work in Sub-Saharan Africa
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Living Reference Work Entry In depth
Decent Work in China
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Article
Open AccessHeterogeneity in top management teams and outward foreign direct investment: evidence from Chinese listed companies
Drawing upon the knowledge-based view and team learning, we investigated how heterogeneity in top management teams (TMTs) in China influences global expansion strategies. Using panel data from Chinese listed f...
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Article
Exosomes from patients with Parkinson’s disease are pathological in mice
Cell-to-cell transport of risk molecules is a highly anticipated pathogenic mechanism in the initiation and progression of various neurodegenerative diseases. Extracellular exosome-mediated neuron to neuron tr...
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Article
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson’s Disease from the Han Population of Chinese Mainland
The genetic factors about the pathogenesis of sporadic Parkinson’s disease (sPD) is not completely clear at present; therefore, we performed a genome-wide association study, high-throughput sequencing analysis...
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Article
A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson’s Disease in the Han Population of Chinese Mainland
Genome-wide association studies (GWAS) on sporadic Parkinson’s disease (sPD) are mainly conducted in European and American populations at present, and the Han populations of Chinese mainland (HPCM) almost have...
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Article
Open AccessEffects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats
Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery system...
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Article
Open AccessDelta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease
The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer’s disease (AD). Despite age being the greatest risk factor for AD,...
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Article
Open AccessCerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management
Cerebrotendinous xanthomatosis (CTX) OMIM#213700 is a rare autosomal-recessive lipid storage disease caused by mutations in the CYP27A1 gene; this gene codes for the mitochondrial enzyme sterol 27-hydroxylase, wh...
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Article
Open AccessJapanese encephalitis accompanied by cerebral venous sinus thrombosis: a case report
Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including ce...
