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Article
Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders
Metabolically healthy obesity refers to obese individuals who do not develop metabolic disorders. These people store fat in subcutaneous adipose tissue (SAT) rather than in visceral adipose tissue (VAT). Howev...
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Article
Open AccessANGPTL3 is a novel HDL component that regulates HDL function
Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and hig...
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Article
Open AccessStudy on the relationship between vitamin D level and macrophage ty** in patients with type 2 diabetes mellitus
Population studies have shown that vitamin D (VitD) deficiency is associated with an increased incidence of type 2 diabetes mellitus (T2DM), VitD deficiency is a potential risk factor for T2DM, and the proport...
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Article
Open AccessTrajectories of glycated hemoglobin of T2DM and progress of arterial stiffness: a prospective study
This study aimed to describe the different trajectories groups of HbA1c during the long-term treatment of diabetes and explore the effect of glycemic control on the progression of arterial stiffness.
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Article
Open AccessEpigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet
Non-alcoholic fatty liver disease (NAFLD) is considered to be one of the most common chronic liver diseases across worldwide. Epigallocatechin-3-gallate (EGCG) derived from extract of green tea and is well kno...
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Article
Open AccessSGLT2 inhibition restrains thyroid cancer growth via G1/S phase transition arrest and apoptosis mediated by DNA damage response signaling pathways
Although the prognosis for most patients with papillary thyroid cancer (PTC) is good, the present treatment is ineffective for 5–10% patients. Several studies found sodium–glucose cotransporter 2 (SGLT2) inhib...
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Article
Open AccessLipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students
The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the associ...
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Article
Open AccessAngiopoietin-like 2 is a potential biomarker for diabetic foot patients
Circulating angiopoietin-like 2 (ANGPTL2) protein levels are known to be significantly increased in numerous chronic inflammatory diseases and are associated with the diagnosis and/or prognosis of cardiovascular ...
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Article
Open AccessAI-based prediction for the risk of coronary heart disease among patients with type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is one common chronic disease caused by insulin secretion disorder that often leads to severe outcomes and even death due to complications, among which coronary heart disease (C...
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Article
Open AccessExpression of ANGPTL2 and its impact on papillary thyroid cancer
Although the most thyroid carcinoma patients have good prognosis, around 20% of papillary thyroid carcinoma (PTC) patients have a high rate of metastasis and recurrence after routine treatment, which causes hi...
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Article
Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL)
The beta-2 adrenergic receptor (β2AR), a member of GPCR, can activate multiple signaling pathways and is an important treatment target for cardiac failure. However, the molecular mechanism about β2AR signaling...
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Article
Open AccessEBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation
Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) suppresses breast cancer cell proliferation, potentially through its regulatory effect on epidermal growth factor receptor (EGFR) signaling, although the ...
