-
Article
LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth
The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, a non-apoptotic form of cell death drive...
-
Article
Open AccessOverexpression of the WRKY transcription factor gene NtWRKY65 enhances salt tolerance in tobacco (Nicotiana tabacum)
Salt stress severely inhibits plant growth, and the WRKY family transcription factors play important roles in salt stress resistance. In this study, we aimed to characterize the role of tobacco (Nicotiana tabacum
-
Article
MiR-181c-5p Regulates Lung Adenocarcinoma Progression via Targeting PRKN
Accumulating evidence indicates that microRNAs (miRNAs) have a vital effect on lung adenocarcinoma. However, the contributions and possible mechanisms of miR-181c-5p to lung adenocarcinoma remain largely uncle...
-
Article
HIV encephalopathy is contributed by macrophages and microglia
-
Article
24-h central pressure is a valuable predictor for left ventricular hypertrophy in non-dialysis patients with chronic kidney disease
The current research on the relationship between 24-h central pressure and 24-h brachial pressure with left ventricular hypertrophy (LVH) is characterised by limited sample size and inconsistent findings. Furt...
-
Article
Open AccessAssociation between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease
It is unclear whether short-term blood pressure variability (BPV) is associated with target organ damage in patients with non-dialysis chronic kidney disease (CKD).
-
Article
Robust non-zero-sum stochastic differential game of two insurers with common shock and CDS transaction
This paper considers the non-zero-sum stochastic differential game problem between two ambiguity-averse insurers (AAIs) with common shock. Each AAI’s surplus process consists of a proportional reinsurance prot...
-
Article
Noninvasive identification of SOX9 status using radiomics signatures may help construct personalized treatment strategy in hepatocellular carcinoma
To develop and validate a radiomics-based model for predicting SOX9-positive hepatocellular carcinoma (HCC) using preoperative contrast-enhanced computed tomography (CT) images.
-
Article
Open AccessRecent progress of CDK4/6 inhibitors’ current practice in breast cancer
Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant activation of the cyclin-dependent kinase 4 and 6 (CDK4/6) pathway, independent of mitogenic signaling, engenders ...
-
Article
Open AccessFusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15
Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. n...
-
Article
A study of the biological effects of low-level light
Low-level light therapy (LLLT), also known as photo biomodulation (PBM), is a type of optical therapy that uses red or near-infrared lasers or light-emitting diodes (LEDs) for medical treatment. The laser wave...
-
Article
Open AccessIP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin
There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring the underlying mechanisms a...
-
Article
Computer-aided diagnosis of distal metastasis in non-small cell lung cancer by low-dose CT based radiomics and deep learning signatures
This study aimed to develop and validate radiomics and deep learning (DL) signatures for predicting distal metastasis (DM) of non-small cell lung cancer (NSCLC) in low-dose computed tomography (LDCT).
-
Article
Analysis of online CSR message authenticity on consumer purchase intention in social media on Internet platform via PSO-1DCNN algorithm
With the deepening of the research on corporate social responsibility (CSR), CSR has become increasingly important to enterprises. It can affect consumers’ willingness to purchase enterprise products. Corporat...
-
Article
The Association Between Neuroticism and Nomophobia: Chain Mediating Effect of Attachment and Loneliness
Nomophobia is the fear feeling unable to communicate via mobile phone or the Internet, which is very common in the technical world. The study aimed to explore the effect of neuroticism on nomophobia among Chin...
-
Article
Identification of common core ion channel genes in epilepsy and Alzheimer’s disease
Although available literature indicates that the incidence of dementia in the epilepsy population and the risk of seizures in the Alzheimer’s disease (AD) population are high, the specific genetic risk factors...
-
Article
Open AccessX-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association met...
-
Article
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial
The combination of immune-checkpoint blockade with chemotherapy for the first-line treatment of advanced triple-negative breast cancer (TNBC) has generated mixed results. TORCHLIGHT is a randomized, double-bli...
-
Article
Open AccessA study on whether deep learning models based on CT images for bone density classification and prediction can be used for opportunistic osteoporosis screening
This study utilized deep learning to classify osteoporosis and predict bone density using opportunistic CT scans and independently tested the models on data from different hospitals and equipment. Results show...
-
Article
A Review of Life Cycle Assessment of Soil Remediation Technology: Method Applications and Technological Characteristics
With increasing complexity of soil contamination and more variety in remediation technologies, remediation alternatives must be assessed thoroughly and urgently. Life cycle assessment (LCA) can be used to anal...
