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Article
Open AccessComprehensive genetic analysis of facioscapulohumeral muscular dystrophy by Nanopore long-read whole-genome sequencing
Facioscapulohumeral muscular dystrophy (FSHD) is a high-prevalence autosomal dominant neuromuscular disease characterized by significant clinical and genetic heterogeneity. Genetic diagnosis of FSHD remains a ...
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Article
MFCC based real-time speech reproduction and recognition using distributed acoustic sensing technology
The distributed acoustic sensing technology was used for real-time speech reproduction and recognition, in which the voiceprint can be extracted by the Mel frequency cepstral coefficient (MFCC) method. A class...
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Article
Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole
A series of chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole was designed and synthesized. Structures of all compounds were characterized by 1H NMR, 13C NMR, 19F NMR, and HRMS. The biologi...
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Article
Efficient Production of Melanin by Aureobasidium Melanogenum Using a Simplified Medium and pH-Controlled Fermentation Strategy with the Cell Morphology Analysis
Natural melanin is a biopolymer with wide application prospects in medicine, food, cosmetics, environmental protection, agriculture, and so on. Microbial fermentation is an important and effective way to produ...
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Article
Open AccessValue of preoperative evaluation of FEV1 in patients with destroyed lung undergoing pneumonectomy - a 20-year real-world study
Clinical guidelines recommend a preoperative forced expiratory volume in one second (FEV1) of > 2 L as an indication for left or right pneumonectomy. This study compares the safety and long-term prognosis of pneu...
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Chapter and Conference Paper
The Effect of Inflation Pressure on the Dielectric Recovery Strength of SF6 Circuit Breakers
SF6 gas is widely used in high-voltage power equipment due to its excellent arc extinguishing performance. During the process of breaking fault current in a circuit breaker, the thermal electrical breakdown probl...
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Article
Reproductive outcomes in couples with recurrent pregnancy loss after embryonic chromosomal microarray analysis
Chromosomal microarray analysis (CMA) has been widely applied to explore the genetic etiology in recurrent pregnancy loss (RPL). However, the reproductive prognosis in RPL couples with different types of chrom...
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Chapter and Conference Paper
LDW-RS Loss: Label Density-Weighted Loss with Ranking Similarity Regularization for Imbalanced Deep Fetal Brain Age Regression
Estimation of fetal brain age based on sulci by magnetic resonance imaging (MRI) is crucial in determining the normal development of the fetal brain. Deep learning provides a possible way for fetal brain age e...
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Chapter and Conference Paper
VaeSSC: Enhanced GRN Inference with Structural Similarity Constrained Beta-VAE
Gene regulatory network (GRN) encodes the intricate molecular interactions that govern the regulation of cell identity, thereby controlling the functions and characteristics of cells. With the emergence of sin...
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Chapter and Conference Paper
Hierarchical Pooling Graph Convolutional Neural Network for Alzheimer’s Disease Diagnosis
Deep learning techniques have found extensive applications in utilizing magnetic resonance imaging (MRI) to support the diagnosis of Alzheimer’s disease (AD). However, existing research primarily focuses on th...
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Article
Open AccessSpatial transcriptomics in development and disease
The proper functioning of diverse biological systems depends on the spatial organization of their cells, a critical factor for biological processes like sha** intricate tissue functions and precisely determi...
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Article
Open AccessComplement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway
Recent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. However, the mechanism regulating the expression of complements ...
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Article
A Roadmap for the Human Gut Cell Atlas
The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique oppo...
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Article
Open AccessArtificial intelligence learning landscape of triple-negative breast cancer uncovers new opportunities for enhancing outcomes and immunotherapy responses
Triple-negative breast cancer (TNBC) is a relatively aggressive breast cancer subtype due to tumor relapse, drug resistance, and multi-organ metastatic properties. Identifying reliable biomarkers to predict pr...
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Article
Open AccessA novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer
Early detection is critical for improving the survival of breast cancer (BC) patients. Exhaled breath testing as a non-invasive technique might help to improve BC detection. However, the breath test accuracy f...
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Article
Array piezoelectric energy harvester with frequency up-conversion in rotational motions: theoretical analyses and experimental validations
Piezoelectric energy harvesters (PEHs) have attracted great attention to solve the power supply issue of wireless sensors in rotational motions. PEHs based on smart structures and physical principles have been...
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Article
Open AccessA case of septic shock due to delayed diagnosis of Cryptosporidium infection after liver transplantation
Cryptosporidium is recognized as a significant pathogen of diarrhea disease in immunocompromised hosts, and studies have shown that Cryptosporidium infection is high in solid organ transplantation (SOT) patients ...
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Article
Open AccessSpatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...
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Chapter and Conference Paper
SSTVC: Carotid Plaque Classification from Ultrasound Images Using Self-supervised Triple-View Contrast Learning
Carotid plaque classification holds significant importance in the clinical practice for evaluating the risk of coronary artery disease (CAD) in patients. While deep supervised learning has been proven to be ef...
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Article
Open AccessRepeated turnovers keep sex chromosomes young in willows
Salicaceae species have diverse sex determination systems and frequent sex chromosome turnovers. However, compared with poplars, the diversity of sex determination in willows is poorly understood, and little i...