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Article
Open AccessFactors associated with clinical nurse’s mental health: a qualitative study applying the social ecological model
The prevalence of burnout, depression, and anxiety among Chinese nurses was 34%, 55.5%, and 41.8% respectively. Mental health problems have significant impacts on their personal well-being, work performance, p...
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Article
Open AccessBleomycin induces senescence and repression of DNA repair via downregulation of Rad51
Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a ...
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Article
Open AccessThe Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury
Oxidative stress is a frequently occurring pathophysiological feature of spinal cord injury (SCI) and can result in secondary injury to the spinal cord and skeletal muscle atrophy. Studies have reported that g...
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Article
Open AccessS100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure
Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 pa...
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Article
Open AccessNitro-fatty acids: mechanisms of action, roles in metabolic diseases, and therapeutics
Nitro-fatty acids (NO2-FAs) are a class of bioactive lipids that mediate metabolic, anti-oxidative stress, anti-inflammatory, and other signaling actions. Endogenously, NO2-FAs are derived from the non-enzymatic ...
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Article
Open AccessChromosome-scale genome assemblies of Himalopsyche anomala and Eubasilissa splendida (Insecta: Trichoptera)
Trichoptera is one of the most evolutionarily successful aquatic insect lineages and is highly valued value in adaptive evolution research. This study presents the chromosome-level genome assemblies of Himalopsyc...
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Article
Correction to : An Oscillation-Free Bound-Preserving Discontinuous Galerkin Method for Multi-Component Chemically Reacting Flows
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Article
Open AccessLASS2 suppresses metastasis in multiple cancers by regulating the ferroptosis signalling pathway through interaction with TFRC
As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes...
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Article
Open AccessWheat Pm55 alleles exhibit distinct interactions with an inhibitor to cause different powdery mildew resistance
Powdery mildew poses a significant threat to wheat crops worldwide, emphasizing the need for durable disease control strategies. The wheat-Dasypyrum villosum T5AL·5 V#4 S and T5DL·5 V#4 S translocation lines carr...
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Article
Open AccessATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia–reperfusion injury
Cardiac resident MerTK+ macrophages exert multiple protective roles after ischemic injury; however, the mechanisms regulating their fate are not fully understood. In the present study, we show that the GAS6-induc...
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Article
Open AccessEffects of slight shading in summer on the leaf senescence and endogenous hormone and polyamine contents in herbaceous peony
Herbaceous peony is a perennial root plant that likes light and is cold-resistant. During summer, high temperature and strong light intensity advance its entry into the leaf wilting stage, which limits the acc...
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Article
Open AccessMacrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression
Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as a...
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Article
Open AccessTargeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T therapy. The potential of combining PD1/PDL1 (Prog...
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Article
Open AccessAbnormal adenosine metabolism of neutrophils inhibits airway inflammation and remodeling in asthma model induced by Aspergillus fumigatus
Neutrophils consume a large amount of energy when performing their functions. Compared with other white blood cells, neutrophils contain few mitochondria and mainly rely on glycolysis and gluconeogenesis to pr...
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Article
Open AccessEstablishment of HIV-negative neurosyphilis risk score model based on logistic regression
To establish the risk scoring model for HIV-negative neurosyphilis (NS) patients and to optimize the lumbar puncture strategy.
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Article
Open AccessHigh TXNIP expression accelerates the migration and invasion of the GDM placenta trophoblast
Our previous study has proofed the glucose sensitive gene-thioredoxin-interacting protein (TXNIP) expression was up in the placenta of the patients with gestational diabetes mellitus (GDM), but the pathologica...
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Article
Open AccessN6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice
Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected individuals. Controlling the excessive production of pro-inflammatory cytokines and subsequent organ dysfunction in...
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Article
Open AccessMechanosensitive Ion Channel TMEM63A Gangs Up with Local Macrophages to Modulate Chronic Post-amputation Pain
Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due to its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency tr...
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Article
Open AccessEffect of crevice density on biological soil crust development on rock cut slope in mountainous regions, Sichuan, China
The rock cut slope (RCS) could cause damage to regional ecological functions and landscapes and requires recovery. Biological soil crusts (BSCs) are pioneer and dominant colonizers during the initial recovery ...
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Article
Open AccessPredictive value of CAC score combined with clinical features for obstructive coronary heart disease on coronary computed tomography angiography: a machine learning method
We investigated the predictive value of clinical factors combined with coronary artery calcium (CAC) score based on a machine learning method for obstructive coronary heart disease (CAD) on coronary computed t...
