244 Result(s)
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Article
Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
Calcific aortic valve stenosis (CAVS) is characterized by increasing inflammation and progressive calcification in the aortic valve leaflets and is a major cause of death in the aging population. This study ai...
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Article
Modelling, Analysis and Control of Non-linear Kinetics of a Planetary Magnetic Gear Motor for a Steering System
A non-linear mathematical model was built to represent the planetary magnetic gear motor in a vehicle steering system. In view of period doubling, quasi-period and chaotic motions in the steering process of th...
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Article
Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
Neoadjuvant immunotherapy with programmed death-ligand 1 blockade for colon cancer, especially for mismatch repair-deficient (dMMR)/high microsatellite instability (MSI-H) colon cancer, has gained considerable...
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Article
Open AccessBleomycin induces senescence and repression of DNA repair via downregulation of Rad51
Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a ...
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Article
In Situ Assembly of Melittin-PHA Microspheres for Enhancing Therapeutic Efficacy in Cancer Treatment
Amphiphilic cationic peptide (ACP) is a widely studied biofilm-active peptide that has great potential in cancer treatment. However, poor stability, a short half-life, and complex preparation pose significant ...
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Analyzing the surface passivity effect of germanium oxynitride: a comprehensive approach through first principles simulation and interface state density
High-purity germanium (HPGe) detectors, which are used for direct dark matter detection, have the advantages of a low threshold and excellent energy resolution. The surface passivation of HPGe has become cruci...
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Open AccessThe Effect of Glycine and N-Acetylcysteine on Oxidative Stress in the Spinal Cord and Skeletal Muscle After Spinal Cord Injury
Oxidative stress is a frequently occurring pathophysiological feature of spinal cord injury (SCI) and can result in secondary injury to the spinal cord and skeletal muscle atrophy. Studies have reported that g...
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Article
Cytogenetic analysis reveals a mechanism of compatibility in distant hybridization between tree peony and herbaceous peony
Cross-incompatibility is the major challenge in inter-sectional distant hybridization between tree peonies (Paeonia sect. Moutan) and herbaceous peonies (Paeonia sect. Paeonia). Most of the intersectional cross c...
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Open AccessS100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure
Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 pa...
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High-frequency ultrasound imaging findings in the diagnosis of segmental schwannomatosis of the ulnar nerve: case report and literature review
Schwannomatosis is characterized by the development of multiple schwannomas without evidence of vestibular tumors. Segmental schwannomatosis is defined as being limited to one limb or five or fewer contiguous ...
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Open AccessNitro-fatty acids: mechanisms of action, roles in metabolic diseases, and therapeutics
Nitro-fatty acids (NO2-FAs) are a class of bioactive lipids that mediate metabolic, anti-oxidative stress, anti-inflammatory, and other signaling actions. Endogenously, NO2-FAs are derived from the non-enzymatic ...
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Open AccessChromosome-scale genome assemblies of Himalopsyche anomala and Eubasilissa splendida (Insecta: Trichoptera)
Trichoptera is one of the most evolutionarily successful aquatic insect lineages and is highly valued value in adaptive evolution research. This study presents the chromosome-level genome assemblies of Himalopsyc...
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Correction to : An Oscillation-Free Bound-Preserving Discontinuous Galerkin Method for Multi-Component Chemically Reacting Flows
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Article
Open AccessLASS2 suppresses metastasis in multiple cancers by regulating the ferroptosis signalling pathway through interaction with TFRC
As a key enzyme in ceramide synthesis, longevity assurance homologue 2 (LASS2) has been indicated to act as a tumour suppressor in a variety of cancers. Ferroptosis is involved in a variety of tumour processes...
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Machine learning–based coronary artery calcium score predicted from clinical variables as a prognostic indicator in patients referred for invasive coronary angiography
Utilising readily available clinical variables, we aimed to develop and validate a novel machine learning (ML) model to predict severe coronary calcification, and further assessed its prognostic significance.
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Article
Cathodic corrosion as a facile and universal method for scalable preparation of powdery single atom electrocatalysts
Top-down strategy has been widely applied for synthesis of metal single atom catalysts (SACs) via converting metal nanoparticles or bulk metals into atomically dispersed species. Here, we report a simple elect...
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Open AccessWheat Pm55 alleles exhibit distinct interactions with an inhibitor to cause different powdery mildew resistance
Powdery mildew poses a significant threat to wheat crops worldwide, emphasizing the need for durable disease control strategies. The wheat-Dasypyrum villosum T5AL·5 V#4 S and T5DL·5 V#4 S translocation lines carr...
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Article
Open AccessATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia–reperfusion injury
Cardiac resident MerTK+ macrophages exert multiple protective roles after ischemic injury; however, the mechanisms regulating their fate are not fully understood. In the present study, we show that the GAS6-induc...
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Article
DEEPBIN: Deep Learning Based Garbage Classification for Households Using Sustainable Natural Technologies
Today, things that are accessible worldwide are upgrading to innovative technology. In this research, an intelligent garbage system will be designed with State-of-the-art methods using deep learning technologi...
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Article
Unveiling thermal properties and pump-out blocking in diamond/GaInSn composites as thermal interface materials
Gallium-based liquid metal, as a high-performance thermal interface material, can improve the performance and service life of electronic equipment. This study focuses on the use of diamond as a thermal conduct...
